血管紧张素Ⅱ受体阻滞剂治疗肥厚型心肌病的Meta分析

Efficacy of angiotensin Ⅱ receptor blocker in hypertrophic cardiomyopathy：A Meta-analysis of randomized clinical trials

目的 使用Meta分析的方法评价血管紧张素Ⅱ受体拮抗剂（ARBs）类药物对肥厚型心肌病（HCM）的疗效.方法 检索Web of Science、PubMed、EMBASE、Cochrane Central Register of Controlled Trials、中国知网（CNKI）、中国生物医学文献光盘数据库（CBMdisk）的文献,纳入与安慰剂或常规治疗相比较的临床随机对照试验,分析ARB类药物治疗HCM的效果.结果 包括228例患者的6个随机对照试验纳入Meta分析.研究显示,ARB类药物对左室射血分数、二尖瓣舒张早期最大血流速度（E）和舒张晚期最大血流速度（A）及左室质量的影响未见统计学差异.结论 ARB类药物对于HCM患者的心脏功能可能没有影响.

Objective To evaluate the efficacy of ARBs as a drug treatment in patients with HCM by us- ing the methods of meta-analysis. Methods Web of Science, PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, CNKI and CBMdisk were searched for pertinent studies. Randomized trials that compared ARBs with placebo or any other control on HCM were included. Results Data from 228 patients in 6 randomized trials were analyzed. This analysis suggested ARBs treatment could not decrease left ventricular ejection fraction, left ventficular mass and increase E/A ratio. Conclusion ARBs might have no effect on cardiac function in HCM.