中枢σ-2受体对神经精神疾病影响和治疗的研究进展

Research advance of central σ-2 receptor on the pathogenesis and therapeutics of neuropsychiatric diseases

中枢σ-2受体可能在神经精神疾病的发病和治疗中起重要作用。近年来,随着新型σ-2受体选择性配体的问世,其神经生物学相关研究取得了长足进展。最新研究发现,孕激素受体膜组分1(progesterone receptor membrane component 1,PGRMC1)可能是σ-2受体的一部分,这为σ-2受体的功能研究提供了新方向。因此,本文就σ-2受体在神经系统中的生理功能,以及σ-2受体对神经精神疾病的影响和治疗的相关研究进展作一综述。

Recent studies indicated that the central σ-2 receptor may play an important role in the pathogenesis and therapeutics of neuropsychiatric diseases.In the recent years,its neurobiological functions have attracted great attention with the emergence of available new selective σr-2 receptor ligands.Several new studies suggest that σ-2 receptor is a part of PGRMC1,shading new light on and direction for the function investigation of σ-2 receptor.Thus,in this review,the physiological functions of σ-2 receptor in the central nervous system,and the involvement of σ-2 receptor in various neuropsychiatric diseases and related treatment are discussed.