高龄慢性阻塞性肺疾病患者长期应用舒利迭的临床观察

Clinical Observation of Long-term Seretide Propionate Aerosol Inhalation Treatment of Elderly Chronic Obstructive Pulmonary Disease

目的探讨高龄慢性阻塞性肺疾病患者长期应用舒利迭的临床疗效和安全性。方法回顾性分析172例在辽宁省金秋医院确诊并接受治疗的高龄慢性阻塞性肺疾病患者。所有患者均在基础治疗上应用舒利迭50μg／250Pg或50μg／500μg吸入治疗，观察治疗前后的肺功能指标变化及临床疗效、治疗后1年加重次数、药物不良反应，并对结果进行统计学分析。结果应用舒利迭治疗后，患者肺功能有改善，但无统计学意义（P〉0．05），患者症状改善明显，临床有效率达87．79％，治疗后1年加重次数均较前改善，药物不良反应发生率较低。结论采用舒利迭吸入治疗高龄慢性阻塞性肺疾病患者可以明显缓解临床症状，安全、有效，可以在高龄慢性阻塞性肺疾病患者中长期应用。

Objective To study the efficacy and safety of Seretide in long-term inhalation for treating the elderly patients with chronic obstructive pulmonary disease. Methods Retrospective analysis of 172 patients with chronic obstructive pulmonary disease in Jinqiu Hospital of Liaoning Province was conducted. On the basis of the routine treatment, all patients were treated with Seretide propionate aerosol inhalation of 50 μg/250 μg or 50μg/500μg. The indexes of pulmonary function before and after treatment, clinical curative effect, times of exacerbation one year after treatment and adverse reactions of medication were observed, and the results were statistically analyzed. Results The pulmonary function after the treatment with Seretide was improved, but there was no statistical significance （P 〉 0.05）. The symptoms of patients were obviously improved with the total clinical effective rate of 87.79%. Times of exacerbation one year after treatment were improved and the incidence of adverse reactions was low. Conclusion Seretide propionate aerosol inhalation treatment of elderly chronic obstructive pulmonary disease can obviously relieve the clinical symptoms with safety and effectiveness, and is fit to long-term utilization in elderly chronic obstructive pulmonary disease.