连续性血液净化技术在重症病毒性脑炎中的应用研究

Application of continuous blood purification for the treatment of severe viral encephalitis

目的研究连续血液净化技术在重症病毒性脑炎中的临床意义。方法收集重症病毒性脑炎患儿,分为治疗组及对照组各15人,在常规治疗基础上给予床边血液净化治疗,并对2组患者的发热持续时间、昏迷持续时间、抽搐持续时间、住院时间、神经元烯特异性醇化酶(neuron-specific enolase,NSE)、S100蛋白及格拉斯哥预后评分(Glasgow outcome scale,GOS)的变化,分别通过t检验及χ~2检验进行比较分析。结果 2组间发热持续时间(t=2.289,P=0.030)、昏迷持续时间(t=3.098,P=0.004)、抽搐持续时间(t=2.348,P=0.026)、住院时间(t=2.213,P=0.035)、S100(t=2.192,P=0.037)、NSE(t=2.841,P=0.008)及GOS(χ~2=4.774,P=0.029)均有差异,2组间差异具有统计学意义。结论血液净化技术在早期重症病毒性脑炎患儿中应用可在一定程度改善患者预后。

Objective To study the clinical significance of continuous blood purification for the treatment of severe viral encephalitis. Methods We recruited 30 children with severe viral encephalitis treated in our hospital and divided them into treatment group（n=15） and control group（n=15）. In treatment group, the patients were treated with continuous blood purification at bedside in addition to the routine therapy for encephalitis.Duration of fever, coma and seizures, hospitalization day, NSE（neuron-specific enolase）, S100 protein and Glasgow Outcome Scale（GOS） were compared between the two groups. t test and X^2 test were used for the analyses. Results The duration of fever, coma and seizures, hospitalization day, NSE level, S100 protein level and GOS were statistically different between the two groups（fever： t=2.289, P=0.030; coma： t=3.098, P=0.004; seizures： t=2.348, P=0.026; hospitalization day： t=2.213, P=0.035; NSE： t=2.841, P=0.008; S100 protein： t=2.192, P=0.037; GOS： χ~2=4.774, P=0.029）. Conclusion Blood purification can improve the prognosis of severe viral encephalitis patients at early stage.