北京朝阳医院精准用药门诊实践

Practice of precision pharmacy clinic

目的:分享北京朝阳医院精准用药门诊模式,总结就诊患者特点和精准用药调整手段,分析开设精准用药门诊的利弊,希望为国内未来精准用药实践提供参考。方法:以2015年6月至2015年12月在北京朝阳医院精准用药门诊就诊的患者作为研究对象,汇总分析患者特点、用药规律、精准用药调整过程及实施精准用药后的药物方案变化,评估调整效果,并估算患者未来获益。结果:在此期间,共接诊患者189例,开展基因检测109人次,开展血药浓度监测5人次。就诊患者中,以心血管疾病患者居多,平均年龄(61.92±11.92)岁,就诊前后,人均减少用药品种(0.5±0.33)种,人均降低药费(365.44±58.35)元/月。结论:实施精准用药指导,可最大限度的实现个体化用药,保障药物疗效,减少药物相关不良反应,并具有明显的经济学价值,可改善患者远期预后,值得临床推广实施。

Objective： To share outpatient mode of Precision Pharmacy Clinic in Belling Chao-yang hospital, summarize characteristics of patients and methods of therapeutic regimen adjustment, so as to provide reference for domestic precision pharmacy implementation. Methods： From June 2015 to December 2015, outpatients visiting Precision Pharmacy Clinic of our hospital were selected into the study. We measured the effect of precision pharmacy by analyzing the patients＇ characteristics, the rules of medication, the processes of adjustment and the changes of therapeutic regimen. Finally we evaluate the patients＇ future benefit from precision pharmacy. Results： During this period, a total of 189 patients visited the outpatient, I09 patients were tested drug-related genes, and 5 patients were monitored blood medication concentration. Patients with cardiovascular disease were the majority of all patients with mean age of 61.92±11.92 years old. The number of medication varieties decreased （0.5±0.33） kinds per capita and medicine expenses of each patients decreased （365.44±58.35）yuan per month. Conclusion： Precision pharmacy could contribute to the realization of the individualized medication, ensure medication efficacy, and reduce medication-related adverse reactions. Precision pharmacy has obvious economic value, can improve long-term prognosis of patients, which deserves popularization and application in clinical.