20例抗菌药物致药物热回顾性分析

Retrospective analysis about 20 cases of drug fever induced by antibiotics

目的:本研究旨在探究抗菌药物所致药物热的特点,以正确地认识药物,避免药物热引起的严重后果。方法:选择呼吸科2011-2014年发生的药物热20例,总结病例特点,对药物种类及实验室检查等结果进行回顾性分析。结果:20例患者在停药后48 h内体温均恢复正常。药物热发生中位时间为用药后第6 d,平均值为6.9 d,下午和夜间体温升高明显,最高温度在37.8~40.3℃之间,20例均出现相对缓脉,部分病例出现了转氨酶和血沉值升高。结论:临床医生应关注抗菌药引起药物热,尽早判断药物热,减少抗菌药的不合理使用。

Objective： To explore the features about drug fever, ensure medicine use correctly and avoid serious consequences caused by drug fever. Methods： 20 cases were included from 2011 to 2014. Characteristics of cases were summarized and the laboratory examination results were retrospectively analyzed in the study. Results： The temperature of 20 patients was back to normal. The median time of drug fever was 6 days, and the mean time was 6.9days. The body temperature was higher in the afternoon or at night. The maximal temperature is 37.8 to 40.3~C. Relatively slow pulse occurred in all cases. Transaminase and blood sedimentation value increased in some cases. Conclusion： Doctors should pay more attention to the drug fever caused by antibiotics in order to decrease the adverse reaction of antibiotics.