血浆微量元素与非酒精性脂肪性肝病的相关性

Correlation of plasma trace elements and non-alcoholic fatty liver disease

目的探讨血浆微量元素与非酒精性脂肪性肝病(NAFLD)的相关性。方法选取体检NAFLD患者30例(A组)及同期健康人群61例(B组),测定两组肝功能酶学指标及血浆微量元素水平,分析NAFLD发生的影响因素。结果 A组BMI和ALT、ALP和γ-谷氨酰转移酶(γ-GT)水平均高于B组,而血浆镍和锌水平低于B组(P<0.05)。以年龄、性别为控制变量行偏相关分析,结果显示,钴与ALT、铁与AST呈正相关,镍、铜与ALP呈负相关(P<0.05)。多因素Logistic回归分析显示,ALP和γ-GT水平升高是NAFLD发生的危险因素(P<0.01),而血浆锌水平的升高可能是NAFLD发生的保护因素(P<0.01)。结论血浆微量元素铁、钴、镍、铜和锌等可能和NAFLD的发生、发展相关,NAFLD患者应注重适当补充微量元素锌。

Objective To analyze the correlation between plasma trace elements and nonalcoholic fatty liver disease（NAFLD）.Methods The enzymology indexes of liver function and plasma trace elements were detected in 30 patients with NAFLD（group A）and 61 healthy people（group B）.The factors influencing the occurrence of NAFLD were analyzed.Results The levels of ALT,ALP,γ-GT and BMI were higher and plasma levels of nickel and zinc were lower in group A than those in group B（P〈0.05）.Taking age and sex as control variables,partial correlation analysis showed that plasma levels of cobalt and iron were positively correlated with those of ALT and AST,and plasma levels of nickel and copper were negatively correlated with those of ALP,respectively（P〈0.05）.Multivariate logistic regression analysis showed that the increased ALP,γ-GT levels were the risk factors and the increased zinc levels were the protective factors for the occurrence of NAFLD（P〈0.01）.Conclusion Trace elements such as iron,cobalt,nickel,copper,zinc may be related directly with the occurrence and development of NAFLD.It is necessary to add zinc appropriately in the patients with NAFLD.