TNFα及PCT对乙型肝炎肝硬化并发自发性细菌性腹膜炎诊断价值

Diagnostic Value of TNFα and PCT of Hepatitis B Cirrhosis Complicated with Spontaneous Bacterial Peritonitis

目的探讨乙型肝炎肝硬化并发自发性细菌性腹膜炎(SBP)患者血清肿瘤坏死因子(TNFα)及降钙素原(PCT)的水平及其临床意义。方法随机选择潍坊市人民医院2015年3月~2016年6月收治的乙型肝炎肝硬化腹水患者80例,按照并发SBP情况分为两组,SBP组和非SBP组,分别行血清TNFα和PCT水平检测,同时行腹水常规检查及细菌培养。结果 SBP患者组血清TNFα和PCT水平明显高于非SBP患者组(均P<0.01),经抗感染治疗1周后SBP患者组血清TNFα和PCT的水平下降(均P<0.05)。结论血清TNFα和PCT的水平检测对SBP的早期诊断与治疗有一定价值。

Objective To investigate the clinical significance of TNFα and PCT levels in hepatitis B cirrhosis complicated with spontaneous bacterial peritonitis. Methods From March 2015 to June 2016,80 patients with hepatitis B with cirrhosis ascites in weifang people＇s hospital were selected,and were divided into two groups according to whether complicated with SBP,SBP group and non SBP group. The levels of serum TNFα and PCT of the two groups were tested and compared. All patients received the routine test of ascites and ascitic bacteri- al culture. Results The levels of TNFα and PCT in SBP group were significantly higher than those in group without SBP （ P 〈 0.0l ）. After antibiotics treatment for one week, the levels of serum TNFα and PCT in SBP group were significantly decreased （ P 〈 0. 05）. Conclusion Serum TNFα and PCT is valuable in the early diagnosis and prognosis judgment of hepatitis B cirrhosis complicated with SBP.