婴儿肝炎综合征与脂溶性维生素D、A、E水平相关性研究

The correlation between infantile hepatitis syndrome and fat-soluble vitamin D, A and E levels

目的：探讨婴儿肝炎综合征（IHS）患儿血浆维生素D、A、E水平的变化，为IHS患儿的治疗提供可靠依据。方法选择2015年1月至2016年5月诊治的IHS患儿73例（IHS组），同时选择健康体检婴儿82例作为健康对照组，检测两组维生素D、A、E水平，并进行比较。结果 IHS组维生素D、A、E水平均低于健康对照组[（37.871±20.111）nmol/L比（97.708±28.827） nmol/L、（1.082±0.657）μmol/L 比（1.810±0.517）μmol/L、（21.252±7.596）μmol/L 比（26.647±6.495）μmol/L]，差异有统计学意义（P＜0.01或＜0.05）。IHS组和健康对照组维生素D、A、E营养状况比较差异均有统计学意义（P＜0.01）。结论 IHS患儿明显存在脂溶性维生素D、A、E缺乏，以维生素D缺乏最为明显。维生素D、A、E可以作为IHS患儿治疗、营养状况和生长发育评估及远期并发症动态监测的指标。

Objective To investigate the change of plasma vitamin D, A and E levels in infant with infantile hepatitis syndrome （IHS） and to provide reliable basis for clinical treatment. Methods Seventy-three infant with IHS （IHS group） from January 2015 to May 2016 and 82 cases of physical examination infant （control group） were enrolled in this study.The levels of plasma vitamin D, A and E were tested and compared between two groups. Results The levels of vitamin D, A and E in IHS group were significantly lower than those in control group：（37.871 ± 20.111） nmol/L vs. （97.708 ± 28.827） nmol/L, （1.082 ± 0.657）μmol/L vs. （1.810 ± 0.517）μmol/L, （21.252 ± 7.596）μmol/L vs. （26.647 ± 6.495）μmol/L, P〈0.01 or 〈0.05. The nutritional status of vitamin D, A and E in two groups had significant differences （P〈0.01）. Conclusions There have obvious deficiency in fat-soluble vitamin D, A and E in infant with HIS , and vitamin D deficiency is the most obvious. The levels of vitamin D, A and E are the dynamic monitoring indicators of treatment, nutritional status evaluation and long-term complicationsnbsp;development.