摘要
肠道菌群是人体胃肠道系统内一个数目庞大的微生物有机群体.近年发现,肠道菌群参与人体心血管、内分泌与代谢等系统生理功能的调节.甲状腺是人体内分泌系统的重要调节器官.碘离子是甲状腺激素分子结构中重要的构成元素;同时,微量元素硒在甲状腺激素T4向L的转化中起到必不可少的作用.肠道菌群的组成结构异常,不仅参与了自身免疫性甲状腺疾病的免疫调节,而且影响甲状腺激素相关物质如外源性甲状腺素、碘以及硒元素的吸收和代谢,进而影响甲状腺稳态.目前,对于肠道菌群与甲状腺稳态的关系,相关研究仅呈现冰山一角,更多、更深入的机制有待进一步探讨.
The intestinal bacteria are the enormous bacteria organism which colonize the intestinal tract.It has been found recently that the intestinal bacteria participate in modulating the multi-system physiology activity,including the cardiovascular system,the endocrine and metabolic system and so on.Thyroid gland is one of the most important organs in the endocrine system.Iodine plays an essential role in the chemical structure of thyroid hormone.Further more,trace mineral selenium is rather important in the conversion of T4 to T3.Once the component of the intestinal bacteria changes,it will not only be associated with the autoimmune thyroid diseases,but also affect the absortion and metabolism of the thyroid hormones and other agents,such as exogenous thyroxine,iodine and selenium.However,current researches focusing on the association between intestinal bacteria and thyroid homeostasis are far from clear enough,and more iceberg unseen may be in the sea.
作者
浮迎迎
刘超
蔡可英
Fu Yingying Liu Chao Cai Keying(Xuzhou Medical University, Xuzhou 221006, China)
出处
《国际内分泌代谢杂志》
2017年第2期98-100,共3页
International Journal of Endocrinology and Metabolism
关键词
肠道菌群
甲状腺
自身免疫
甲状腺素
碘
硒
Intestinal bacteria
Thyroid
Autoimmune
Thyroxine
Iodine
Selenium
