成纤维细胞生长因子-23的代谢调控及与疾病的关系

The metabolic regulation of fibroblast growth factor-23 and its relation with diseases

成纤维细胞生长因子-23（FGF-23）是一种重要的骨源性调磷激素,其主要受体为成纤维细胞生长因子受体（FGFR）/Klotho复合物.多种因素共同参与FGF-23的生理及病理性调控.FGF-23的主要生理作用为调节磷和维生素D代谢.FGF-23的代谢耦联失衡可导致多种磷代谢异常疾病,如X连锁遗传性低血磷性佝偻病、常染色体显性遗传性低血磷性佝偻病、常染色体隐性遗传性低血磷性佝偻病和肿瘤性骨软化症等.随着研究的深入,已明确高水平的FGF-23在慢性肾脏疾病和心血管疾病中发挥重要的病理作用,其精确的调控网络及分子机制仍有待阐明.此外,新近的研究已初步探讨了FGF-23在糖、脂代谢中的作用.

Fibroblast growth factor （FGF）-23 is a bone-derived hormone that is mainly binded to FGF receptor/Klotho combination.Numerous factors have been implicated in the physiological and pathological regulation of FGF-23 expression.FGF-23 has been originally shown to function as a central regulator of phosphate and vitamin D metabolism.Disruption of FGF-23 in metabolic homeostasis plays a significant role in the pathogenesis of phosphate-associated diseases,including X-link dominate hypophosphatemic rickets,autosomal dominant hypophosphatemic rickets,autosornal recessive hypophosphatemic rickets and tumor-induced osteomalacia.Accompanied with further studies,high level of FGF-23 is pathologically involved in the development of chronic kidney disease and cardiovascular disease.The precise metabolic regulation and molecular mechanisms of FGF-23 underlying these conditions remain to be elucidated.Moreover,the emerging roles of FGF-23 in glucose and lipid metabolism have been investigated.