婴幼儿单纯乳房早发育的病因研究进展

The progress of isolated premature thelarche pathogeny in infants and toddlers

据相关流行病学资料,单纯乳房早发育在婴幼儿并不少见;部分患儿的单纯乳房早发育会发展为中枢性性早熟,导致其成年终身高受损,并给其心理健康留下隐患.因此明确婴幼儿单纯乳房早发育的病因对其治疗非常重要.除了生理性小青春期、疾病（卵巢囊肿）及遗传因素外,它的病因还包括误服某些药物、生活环境和营养因素.其中前者是内因,或机体自身分泌雌激素增多,或乳房的雌激素受体对雌激素敏感性增加;后者为外因,或食道摄入雌激素或类雌激素增多,或环境影响（光照、迁徙、环境内分泌干扰物）.

Isolated premature thelarche（IPT） in infants and toddlers are not uncommon,according to the relevant epidemiological data;there is a possibility that IPT may deteriotare into central precocious puberty,causing the lower final height in their adulthood and probably making a negative impact on their mental health while growing old.Therefore,to make clear the pathogeny of IPT in infants and toddlers is critical to treatment.In addition to the physiological ＆quot; mini-puberty＆quot;,disease （ovarian cyst） and genetic factor,IPT also results from some drugs,living environment and nutrition.Among which,the former are endopathic factors that either organism secrete too much oestrogen or oestrogen receptors of breast tissue become more sensitive to oestrogen;the latter are exopathic factors that either much more oestrogen or oestrogen-like substance is taken or environmental influence （lighting,migration,endocrine disrupting chemicals）.