代谢综合征患者白细胞介素6与血清多不饱和脂肪酸相关性

Relationship between interleukin-6 and serum polyunsaturated fatty acids in patients with metabolicsyndrome

目的 研究代谢综合征患者血清磷脂多不饱和脂肪酸（PUFA）与白细胞介素6（IL-6）的关系。方法 61例代谢综合征患者和55例健康对照者用高效气相色谱法测定血清PUFA谱，酶联免疫吸附试验法测定血清IL-6水平。结果 代谢综合征组的血清IL-6明显高于健康对照组［（16.0±4.7）pg/ml 比（9.2±2.6）pg/ml，P=0.000］。代谢综合征组的总PUFA百分含量明显低于对照组［（47.2±2.4）% 比（50.8±2.5）%，P=0.001］。相关性分析显示IL-6浓度与n-3 PUFA总量（r=-0.51，P＜0.01）、n-6 PUFA总量（r=-0.27，P＜0.01）及 PUFA总量呈负相关（r=-0.38，P＜0.01）。结论 代谢综合征患者血清PUFA低于健康者，血清IL-6与PUFA总量呈负相关。

Objective To investigate the relationship between serum phospholipid polyunsaturated fatty acids （PUFA） and interleukin-6 （IL-6） in patients with metabolic syndrome. Methods Serum phospholipid PUFA profiles of 61 patients with metabolic syndrome and 55 healthy controls was analyzed with high performance gas chromatography. Enzyme-linked immunosorbent assay was used to measure serum IL-6 levels. Results The IL-6 concentration was significantly higher in the MS group than in the control group [（16.0±4.7）pg/ml vs. （9.2±2.6）pg/ml, P=0.000]. The total PUFA percentage was lower in the MS group than in the control group [（47.2±2.4）% vs. （50.8±2.5）%, P=0.001]. The serum IL-6 concentration was negatively correlated with n-3 PUFA, n-6 PUFA, and total PUFA （r=-0.51, P〈0.01; r=-0.27, P〈0.01; r=-0.38, P〈0.01）. Conclusions Serum PUFA in patients with metabolic syndrome is lower than in healthy people. Serum IL-6 concentration may be negatively correlated with total PUFA concentration.