拉氧头孢联合泼尼松治疗急性附睾炎的临床疗效及预后效果分析

Clinical efficacy and prognosis analysis of latamoxef and prednisone for treatment of acute epididymitis

目的:应用拉氧头孢联合泼尼松治疗急性附睾炎,评估其临床疗效及预后,为急性附睾炎的临床诊治提供依据。方法:选择2014年1月至2015年12月本院诊治的急性附睾炎患者80例,随机分为对照组和研究组,两组各40例,对照组患者应用拉氧头孢进行治疗,研究组患者应用拉氧头孢联合泼尼松治疗。评估两组患者临床疗效、患者治疗前后精液质量,观察患者症状体征改善时间和治愈时间。结果:研究组患者总有效率为82.50%(33/40),高于对照组的62.50%(25/69),差异有统计学意义(P<0.05);研究组治疗后精子密度、精子活动率和a+b活力分别为(34.39±2.81)×106/m L、(82.71±5.18)%和(53.59±5.31)%,均高于对照组治疗后的(29.47±2.76)×106/m L、(79.48±5.63)%和(50.38±5.27)%,差异有统计学意义(P<0.05);研究组治疗后精子畸形百分比为(23.84±3.92)%,低于对照组治疗后的(27.48±2.86)%,差异有统计学意义(P<0.05);研究组患者体温降至正常时间、疼痛缓解时间和治愈时间分别为(2.96±0.42)d、(3.09±0.71)d和(7.74±0.86)d,低于对照组的(3.83±0.45)d、(3.09±0.71)d和(10.82±0.91)d,差异有统计学意义(P<0.05)。结论:应用拉氧头孢联合泼尼松治疗急性附睾炎能够显著提高患者临床疗效,缩短患者症状体征改善时间和治愈时间,还能够显著提高患者精子质量。

Objectives： To analyze the clinical efficacy and prognosis of latamoxef and prednisone treatment of acute epididymitis,so as to provide basis for its clinical treatment. Methods： 80 patients with acute epididymitis treated in our hospital from January 2014 to December 2015 were selected and randomly divided into control group and study group,with 40 cases in each group. Control group received latamoxef treatment,and study group received latamoxef and prednisone treatment. The clinical efficacy and semen quality before and after treatment in the two groups were evaluated. The symptoms improvement time and healing time were observed. Results： The total effective rate of study group was 82. 50%（ 33/40）,which was higher than that of control group 62. 50%（ 25/69）,with statistically significant difference（ P〈0. 05）. The sperm concentration,sperm motility and a ＋ b vitality of study group after the treatment were respectively（ 34. 39 ± 2. 81） × 106/m L,（ 82. 71 ± 5. 18） % and（ 53. 59 ± 5. 31） %,which were higher than theses of control group after treatment,（ 29. 47 ± 2. 76） × 106/m L,（ 79. 48 ± 5. 63） % and（ 50. 38 ± 5. 27） %,with statistically significant difference（ P〈0. 05）. The sperm deformity percentage of study group after treatment was（ 23. 84 ± 3. 92） %,which was lower than that of control group（ 27. 48 ± 2. 86） %,with statistically significant difference（ P〈0. 05）. The time of body temperature returning to normal,pain relief time and healing time of study group were（ 2. 96 ± 0. 42） d,（ 3. 09 ± 0. 71） d and（ 7. 74 ± 0. 86） d,which were less than these of control group（ 3. 83 ± 0. 45） d,（ 3. 09 ± 0. 71） d and（ 10. 82 ± 0. 91） d,with statistically significant difference（ P〈0. 05）. Conclusion： Latamoxef combined with prednisone for the treatment of acute epididymitis can significantly improve clinical outcomes and shorten symptoms improvement time and healing time,hereby significantly improving sperm quality of patients.