汉防己甲素治疗结缔组织病相关间质性肺疾病临床疗效观察

Clinical observation of Tetrandrine in treating pulmonary interstitial fibrosis caused by connective tissue disease

目的观察汉防己甲素治疗结缔组织病相关间质性肺疾病(interstitial lung disease associated with connective tissue disease,CTD-ILD)的临床疗效。方法将2014年3月至2016年3月在陆军总医院风湿科就诊且符合纳入标准的32例CTD-ILD患者随机分为两组,每组各16例,对照组给予糖皮质激素和免疫抑制剂治疗;治疗组在上述治疗基础上加用汉防己甲素40mg,1日3次口服,两组疗程均为3个月。结果两组患者治疗后对照组的有效率为53.33%,治疗组的有效率为87.50%,两组比较差异有显著性(P<0.05);治疗后两组患者的动脉血氧分压以及用力肺活量、肺总量、肺一氧化碳弥散量等肺功能指标与治疗前比较均有明显改善(P<0.01),而治疗组患者在上述各项指标的改善上均明显优于对照组(P<0.05)。在治疗中,两组患者均未发生明显的不良反应。结论汉防己甲素治疗CTD-ILD有较好的临床疗效,能明显改善患者的肺功能。

Objective To observe the effect of tetrandrine in treating connective tissue disease caused interstitial lung disease（CTD-ILD）. Method 32 case of CTD-ILD were randomly divided into two groups, each group 16 cases.Corticosteroids and immunosuppressive therapy were given to the control group. The treatment group on the basis of the above treatment with tetrandrine 40 mg, 3 times a day orally, the course of treatment was three months for both groups. Result After treatment, the effective rate in the control group was 53.33%, in the treatment group was 87.50%, and there was significant difference between the two groups（P〈0.05）. After the treatment, the arterial partial pressure of oxygen and forced vital capacity, total lung capacity, diffusion capacity for carbon monoxide of lung were significantly improved than before（P〈0.01）, while the treatment group the various indicators improved significantly better than those of control group（P〈0.05）. Conclusion Tetrandrine has good clinical curative effect in treating connective tissue disease related interstitial lung disease, it can significantly improve the patient＇s lung function.