沙利度胺治疗复发性口疮对患者血清C3、C4补体及免疫球蛋白的影响分析

Analysis on the influence of serum C3,C4 complement and immunoglobulin of thalidomide in the treatment of recurrent aphthous ulcer

目的探讨沙利度胺治疗复发性口疮对患者血清C3、C4补体及免疫球蛋白的影响。方法选取2014年3月至2015年3月本院接诊的100例复发性口疮患者作为本次研究对象。随机分为对照组和观察组,对照组采用传统常规治疗法,观察组给予沙利度胺治疗。观察两组患者CD3、CD4、CD8水平、Ig G、Ig A、Ig M水平、补体C3、补体C4治疗前后水平对比、疗效情况对比。结果治疗前,观察组CD3、CD4、CD8与对照组比较无明显差异,治疗后,均优于对照组,差异具有显著性(P<0.05);治疗前,观察组Ig G、Ig A、Ig M水平与对照组无明显差异,治疗后,均小于对照组,差异具有显著性(P<0.05);治疗前,观察组补体C3、C4与对照组无明显差异,治疗后,均优于对照组,差异具有显著性(P<0.05);观察组疗效82.00%(41/50)优于对照组58.00%(29/50),差异具有显著性(P<0.05)。结论沙利度胺对治疗复发性口疮有显著的效果,能够改善患者血清补体C3、C4及调整免疫球蛋白。

Objective To investigate the effect of thalidomide in the treatment of recurrent aphthous ulcer on the serum C3, C4 complement and immunoglobulin. Method 100 cases of patients with recurrent aphthous ulcer from March 2014 to March 2015 in our hospital were researched. They were divided randomly into observation and control groups. The control group was treated with conventional therapy,the observation group received the treatment of thalidomide. The levels of CD3, CD4, CD8, Ig G, Ig A, Ig M, C3, C4 were observed in the two groups. Result Before treatment,observation group CD3, CD4, CD8 and control group had no obvious difference; After treatment, observation group CD3, CD4, CD8 are better than the control group, the difference was statistically significant（P〈0.05）; Before treatment, observation group Ig G, Ig M, Ig A level and control group had no obvious difference; after treatment, observation group Ig G, Ig M, Ig A level are less than the control group, the difference was statistically significant（P〈0.05）; before treatment, observation group C3, C4 and control group had no obvious difference; after treatment, observation group C3, C4 are better than the control group, the difference was statistically significant（P〈0.05）; observation group curative effect 82.00%（41/50） better than control group58.00%（29/50）, the difference was statistically significant（P〈0.05）. Conclusion Thalidomide has significant effect on the treatment of recurrent aphthous ulcer, can improve the serum C3 and C4 immune globulin complement and adjustment.