多因素与大肠杆菌蛋氨酸合成代径的关系

Relationship Between Multifactors and Metabolism of Methionine Synthesis in Escherichia Coli

蛋氨酸是人体必需的8种基本氨基酸之一。蛋氨酸生物合成途径受多因素作用,包括水解酶,维生素B12,硫供应平衡的调控,末端代谢产物对合成关键基因的阻遏及抑制,阻遏蛋白Met J和乳酸对蛋氨酸代谢合成的阻遏及抑制,及蛋氨酸在菌体内的转运等。本文介绍了与蛋氨酸生物合成相关的影响因素。

methionine is one of the eight basic amino acids necessary for human body.Methionine biosynthesis pathway is affected by many factors including hydrolase,vitamin B12,regulation of sulfur supply balance,repression and inhibition of key metabolites by synthetic metabolites,repression and inhibition of methionine metabolism by Met J and lactate,and methionine transport in bacteria.The factors associated with methionine biosynthesis is des cribed in this paper.