摘要
目的研究经伤椎椎弓根植入纳米羟基磷石灰/聚酰胺(nanohydroxyapatite/polyamide-66,n-HA/PA66)复合人工骨粒对损伤胸腰椎体的生物力学属性恢复效果,探究其临床应用价值。方法选取10具人体T12-L2节段脊柱标本,将其随机平分为两组:自体松质骨组(Cancellous Bone,CB)与n-HA/PA66(NHP)组。椎体损伤后经椎弓根植入上述填充物,并自主设计夹具,利用万能试验机在轴向、前屈、后伸及侧弯四个方向测试椎体功能段T12-L2的刚度与椎体L1的应变。结果研究结果发现,与CB组相比,NHP组在轴向、前屈及侧弯方向上重建椎体刚度显著增加(p<0.05),椎体L1应变显著降低(p<0.05),表明NHP能较好的恢复损伤椎体的生物力学属性。结论 n-HA/PA66骨替代物比松质骨能更好的恢复损伤胸腰椎骨的生物力学性质,具有一定的临床应用价值。
In this paper,the effects of n-HA/PA66 as the transpedicular graft material in biomechanical properties in treating thoracolumbar fractures was addressed,and investigated the value of clinic application.Methods：Ten T12-L2 vertebrae were harvested from human cadavers and randomized devided into two groups：Cancellous Bone（CB） and n-HA/PA66（NHP）.Implant the graft material after vertebral injure,measured the stiffness of functional units（T12-L2） and strain of L1 by the use of self-designed fixture and material testing machine.Results：Our results show that,compared to CB,the stiffness of T12-L2 was significantly increased in NHP（p0.05）,and the strain of L1 was significantly decreased（p0.05）,demonstrating that NHP can better recover the biomechanical properties of injured vertebra.Conclusions：n-HA/PA66 is better than cancellous bone in mechanics for reconstruction of thoracolumber fractures,having some clinical value.However,n-HA/PA66 grafts alone can not recover the biomechanical properties of injured vertebra to that of intact vertebrae,so further studies are needed.
出处
《生命科学仪器》
2017年第1期22-25,21,共5页
Life Science Instruments
基金
国家自然科学基金青年基金(编号:31400805)
