促淋巴管生长因子与NSCLC淋巴管新生及转移的研究进展

Role of lymphangiogenic factors in NSCLC lymphangiogenesis and lymphatic metastasis

淋巴结转移是非小细胞肺癌（NSCLC）及其他恶性肿瘤重要的不良预后因素之一.研究表明,NSCLC及癌旁组织中存在大量淋巴管新生,并且在促进肿瘤细胞淋巴结转移过程中发挥重要作用.目前研究发现NSCLC淋巴管新生及转移受多种促淋巴管生长相关因子的调节,现对其研究进展作一综述.

Lymph node metastasis is one of the main poor prognosis factors for patients with non-small cell lung cancer（NSCLC）and other malignant tumors.Studies have confirmed that there is plenty of intratumoral and peritumoral lymphangiogenesis in the NSCLC,which plays a significant role in the process of neoplastic cell lymph nodes metastasis.The present researches have suggested that lymphangiogenesis and lymph nodes metastasis of NSCLC are regulated by many lymphangiogenic factors.The research progress about it is reviewed.