摘要
目的评价健脾固肾方联合维生素E和人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)治疗早期先兆流产的疗效。方法将符合入选标准的154例早期先兆流产患者,采用随机数字表法分为2组,每组77例。对照组肌肉注射HCG联合维生素E治疗,观察组在对照组基础上配合服用健脾固肾方治疗。2组均治疗2周。分别于治疗前后采用放射免疫分析法检测血清β-HCG水平,采用电化学发光法检测孕酮水平,评价临床疗效。结果观察组总有效率为90.9%(70/77)、对照组为77.9%(60/77),2组比较差异有统计学意义(χ2=-4.936,P=0.026)。治疗后,观察组血清β-HC6[(22383.41±4387.67)m/U/ml比(15728.66±3375.93)mlU/ml,t=5.614]、孕酮[(58.534-18.77)nmol/L比(43.45±17.46)nmol/L,t=2.674]水平均高于对照组(P〈0.01)。结论健脾固肾方联合维生素E和HCG可升高血清β-HCG及孕酮水平,提高临床疗效。
Objective To evaluate the efficacy of Jianpi-Gushen decoction combined with vitamin E and human chorionic gonadotropin for the patients with threatened abortion in early pregnancy. Methods A total of 154 patients with threatened abortion who met the inclusion criteria were divided into two groups by a random digital table, with 77 patients in each. The control group was treated with intramuscular injection of human chorionic gonadotropin (HCG) combined with vitamin E, while the observation group was treated with Jianpi-Gushen decoction based on the treatment of control group. The levels of serum β-HCG were detected by radioimmunoassay before and after treatment, and the levels of progesterone were detected by electrochemiluminescence assay, and the efficacy was evaluated. Results The total effective rate in the observation group was 90.9% (70/77), and control group was 77.9% (60/77). The difference between two groups was significantly different (χ2=4.936, P=0.026). The serum β-HCG level (22 383.41 ± 4 387.67 mIU/ml vs. 15 728.66 ± 3 375.93 mIU/ml, t=5.614) and progesterone level (58.53 ± 18.77 nmol/L vs. 43.45 ± 17.46 nmol/L, t=2.674) in the observation group after treatment were higher than those in the control group (P〈0.01). Conclusions The Jianpi-Gushen decoction combined with vitamin E and HCG could increase the levels of serum β-HCG and progesterone and improve the clinical effect.
出处
《国际中医中药杂志》
2017年第3期215-217,共3页
International Journal of Traditional Chinese Medicine
关键词
流产
先兆
孕酮
绒毛膜促性腺激素
Β亚单位
人
健脾固.肾方
Abortion, threatened
Progesterone
Human chorionic gonadotropin, beta subunit, human
Jianpi-Gushen decoction