基于微气泡的超声分子影像探针及其研究进展

Progress in ultrasound molecular imaging probe based on microbubbles

微气泡是超声成像的传统造影剂,从而也成为超声分子成像中最重要的一类探针载体,多模态、多功能、智能化是微气泡类分子探针的发展趋势。近年来一批设计新颖、功能多样的微气泡类分子探针陆续出现,文章在阐述传统微气泡分子探针发展状况的基础上,对融合多种成像方式的多模态微气泡分子探针、诊疗一体化的多功能微气泡分子探针、由特殊病理环境触发的刺激响应型超声分子探针及组织穿透力更强的纳米尺度超声分子探针,在设计思路及研究现状等方面进行了综述。

Objective：Microbubble is a kind of traditional contrast agent for ultrasound imaging and also one of the most important probe carriers for ultrasound molecular imaging. The developing trend of molecular probes on microbubbles is to multimodal,multifunctional and intelligent. Now there have been lots of novel and multifunctional molecular probes developed based on microbubbles in recent years. This review summarized the design and application of different types of ultrasound molecular probes. It includes multimodal molecular probes of various imaging modes,multifunctional molecular probes of integration of diagnosis and therapy,stimulated response ultrasound molecular probes triggered by special pathological conditions and enhanced tissue penetration ultrasound molecular nano-probes.