降钙素原在细菌感染性疾病诊断与预后中的价值

The study of diagnostic and prognostic values of procalcitonin in bacterial infectious diseases

降钙素原（PCT）是降钙素的前体物质，在严重细菌、病毒与真菌等感染以及脓毒症、多脏器衰竭时其水平常升高，尤其与细菌感染程度密切相关，在临床上对细菌感染和非细菌感染具有重要鉴别诊断作用。本文简要阐述了PCT的由来、一般特性及其在常见细菌感染性疾病如肺炎、胰腺炎、脓毒症中的诊断价值与不足，以期为感染性疾病中PCT单独或与其他指标联合检测细菌感染明确诊断与预后判定提供循证依据。

Procalcitonin （PCT） is the precursor of calcitonin. When serious bacterial, virus, and fungal infection, sepsis and multiple organ failure occurred, PCT concentrations are markedly increased. The level of plasma PCT, which is closely related to the severity of bacterial infections, plays an important role in differential diagnosis of bacterial infection and non-bacterial infection. This paper gives a brief description of the origins and general characteristic of PCT, and the diagnostic value of PCT in the common bacterial infection such as pneumonia, pancreatitis, sepsis, etc. The expected results are intended to provide evidences for accurately diagnosis and prognosis of single and multiple use of PCT and other inflammatory biomarkers.