冠心病患者心率变异与氨基末端脑钠肽前体的相关性研究

Study on the Correlation between Heart Rate Variability and N-Terminal Pro-Brain Natriuretic Peptide Value in Coronary Heart Disease

目的探讨冠心病患者的心率变异性(heart rate variability,HRV)与氨基末端脑钠肽前体(N-Terminal pro-Brain Natriuretic Peptide,NT-proBNP)的相关性。方法选取71例非冠心病患者及52例冠心病患者,完成动态心电图,选时域指标中SDANN代表HRV,采用电化学发光法测量NT-proBNP,分析HRV与NT-proBNP的相关性;结果冠心病组与非冠心病组相比,其HRV降低[(93.27±25.05)ms比(103.00±24.15)ms],而NTproBNP升高[(283.56±518.76)pg/m L比(60.07±104.31)pg/m L],其差异有极显著性意义(P<0.01);并且HRV与NT-proBNP呈负相关(r=-0.202,t=-2.015,P=0.047)。结论冠心病患者HRV及NT-proBNP发生改变,同时HRV是NT-proBNP水平的独立影响因素。

Objective To study the changes of heart rate variability （HRV） and N - Terminal Pro - Brain Natriuret- ic Peptide （NT -proBNP） and illustrate the correlation between heart rate variability （HRV） and NT- proBNP in coronary heart disease （CHD）. Methods Two groups of participants were studied in this study： 71 patients without CHDpatients and 52 patients with CHD. The time domain parameters of 24 hours HRV were detected by 24 hour electrocardiographic monito- ring; NT- proBNP was measured by electrochemiluminescence in these patients. Results The HRV value ~ （93.27 _＋ 25.05 ） ms vs （ 103.00 ＋ 24. 15 ） ms ] was lower and the NT - proBNP value [ （ 283.56 ＋ 518.76 ） pg/mL vs （ 60. 07 -＋ 104. 31 ） pg/mL] was higher in Group A than those in Group B （P 〈0. 01 ） , and HRV value was negatively correlation with NT - proBNP（ r = - 0. 202, t = - 2. 015,P = 0. 047 ）. Conclusion The HRV value and the NT - proBNP value in CHD pa- tients changed, which suggest that lower HRV is a potential risky factor that may affect the NT - proBNP value in patients with CHD.