四逆四妙散加味对湿热瘀结型慢性盆腔炎患者炎性因子及免疫指标的影响

Effect of modified Sini Simiao powder on inflammatory factors and immune indexes in patients with chronic pelvic inflammatory disease of accumulation and stasis of damp-heat

目的:观察四逆四妙散加味对湿热瘀结型慢性盆腔炎患者炎性因子与免疫指标的影响。方法:选择90例湿热瘀结型慢性盆腔炎患者为研究对象,以随机数字表法分组,治疗组与对照组各45例,对照组采取常规抗生素静脉滴注治疗,治疗组配合四逆四妙散加味治疗,对两组患者治疗前后炎性因子及免疫指标变化进行观察。结果:治疗组总有效率为95.56%,对照组为77.78%,两组差异有统计学意义(P<0.05);治疗组IL-6、hs-CRP、IL-8等炎性因子指标水平均低于对照组,差异有统计学意义(P<0.05);治疗组治疗后T淋巴细胞亚群水平与对照组相比,差异有统计学意义(P<0.05)。结论:四逆四妙散加味治疗湿热瘀结型慢性盆腔炎效果满意,可有效控制炎性因子水平,提高机体免疫功能,对降低复发率,改善预后具有积极作用。

Objective： To observe the effect of modified Sini Simiao powder on inflammatory factors and immune indexes in patients with chronic pelvic inflammatory disease of accumulation and stasis of damp-heat. Methods： 90 cases of patients with chronic pelvic inflammatory disease of accumulation and stasis of damp-heat were selected as researched objects and divided randomly into treatment group and control group,45 cases in each group.The control group was treated with intravenous drip of routine antibiotics,while the treatment group was treated in combination with modified Sini Simiao powder. The changes of inflammatory factors and immune indexes of patients were observed before and after treatment in two groups. Results： The total effective rate in treatment group was 95. 56%,while in control group 77. 78%,and the difference between two groups was statistically significant（ P〈0. 05）. The level of indexes of IL-6,hs-CRP,IL-8 etc. inflammatory factors in treatment group was lower than that in control group,and the difference was statistically significant（ P〈0. 05）. Compared the level of T lymphocyte subsets after treatment in treatment group with that in control group,the difference was statistically significant（ P〈0. 05）. Conclusion： The effect of modified Sini Simiao powder on chronic pelvic inflammatory disease of accumulation and stasis of damp-heat is satisfactory,which can effectively control the level of inflammatory factors,improve the immune function of body,and has a positive effect on reduction of recurrence rate and improvement of prognosis.