摘要
目的:探讨多囊卵巢综合征(PCOS)患者采用培坤丸与去氧孕烯炔雌醇片联合治疗的临床疗效,以及对激素的影响。方法:选取我院2014年12月至2015年12月收治的83例PCOS患者作为本次研究对象,按随机数字表法分为对照组和观察组,对照组41例行单纯去氧孕烯炔雌醇片治疗,l片/次,1次/d,观察组42例行培坤丸与去氧孕烯炔雌醇片联合治疗,去氧孕烯炔雌醇片1片/次,1次/d,培坤丸9g/次,2次/d。观察3个月后,比较两组激素、体质量以及脂代谢等各项指标。结果:观察组治疗后的激素水平,包括促卵泡刺激素(FSH)、黄体生成素(LH)、血清总睾酮(T)等均明显优于对照组,两组差异显著(P〈0.05);观察组治疗后的体质量、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL—C)、高密度脂蛋白胆固醇(HDL—C)水平均明显优于对照组,两组差异显著(P〈0.05)。结论:对PCOS患者行培坤丸与去氧孕烯炔雌醇片联合治疗,可明显改善患者的体质量、脂代谢情况,增加FSH水平,降低LH、T水平。
Objective: To explore polycystic ovary syndrome(PCOS) patients with clinical efficacy peikun pill with desogestrel and ethinylestradiol tablets of combination therapy, and the influence on hormones. Methods : Our hospital from December 2014 to December 2015 were treated 83 cases of PCOS patients as this study, were randomly divided into control group and observa- tion group. The control group have 41 simple routine desogestrel and ethinylestradiol tablets treatment, 1 / time, 1 time/d, and the observation group have 42 routine peikun pill desogestrel and ethinylestradiol tablets combination therapy, desogestrel and ethinylestradiol tablets 1/time, 1 time/d, Peikun pill 9 g / time, 2 times/d. Observation 3 months after the index compared be- tween the two groups of hormones, body weight and lipid metabolism. Results: The observation group after treatment of hormone levels, including FSH, LH, T etc than the control group, two groups were significantly different( P 〈 0.05 ) ;body mass the ob- servation group after treatment, TC, TG, LDL-C, HDL-C were significantly better than the control group, two groups were sig- nificantly different ( P 〈 0.05 ). Conclusion : For PCOS patients peikun pills with desogestrel and ethinylestradiol tablets combi- nation therapy can significantly improve the patient's body weight, lipid metabolism, increased FSH levels, reduce LH, T levels.
出处
《中国药物评价》
2017年第1期46-48,共3页
Chinese Journal of Drug Evaluation
关键词
PCOS
培坤丸
去氧孕烯炔雌醇片
激素
PCOS
Peikun pill
Desogestrel and ethinylestradiol tablets
Hormone