饮茶型氟中毒与饮水型氟中毒成人生化测定分析

Biochemical assay of brick-tea fluorosis and drinking-water fluorosis

目的探讨饮茶型氟中毒病区牧民与饮水型氟中毒病区居民血液生化有无差异。方法随机选择16~55岁饮茶型氟中毒病区牧民79人,饮水型氟中毒病区居民92人,男女均衡。测定饮水、奶茶、尿氟铝含量,同时检查氟斑牙,拍摄右前臂及骨盆正位X线片,检测血清电解质及生化指标。氟采用离子选择电极法,铝、钙、磷采用ICP-AES法检测,血清酶类、BUN、CREA、UA、CO2结合率用日本奥林巴斯AU-400全自动生化分析仪检测。结果血铝、钙、BUN、CREA、CO2结合率饮茶型氟中毒病区牧民明显高于饮水型氟中毒病区居民。TBIL、DBIL、IDBIL饮水型氟中毒病区居民高于饮茶型氟中毒病区牧民。结论饮茶型氟中毒病区牧民与饮水型氟中毒病区居民生化改变有明显不同,其发病机理较为复杂,可能与所饮用砖茶氟、铝含量较高有关。

Objective To investigate the differences in the blood biochemistry between brick-tea fluorosis and drinking-water fluorosis. Methods A total of 79 patients with brick-tea fluorosis and 92 patients with drinking-water fluorosis were randomly selected. All patients aged 16-55 years. The contents of fluoride and aluminum in tea, water and urine were detected. Dental fluorosis was evaluated. X-ray examination of the right forearm and pelvis was conducted. Serum electrolytes and biochemical indicators were assessed. The content of fluoride was detected with selective electrode method. The contents of aluminum, calcium and phosphorus were detected with ICP-AES method. Serum enzymes, BUN, CREA, UA and CO2 were detected with Olympus AU-400 Automatic Biochemical Analyzer. Results The contents of BUN, CREA, and CO2 in brick-tea fluorosis were significantly higher than those in drinking-water fluorosis. The contents of TBIL, DBIL and IDBIL in drinking-water fluorosis were higher than those of drinking-water fluorosis. CoflclusiOnThe biochemical changes of residents in the endemic area are significantly different between brick-tea fluorosis and drinking-water fluorosis. The pathogenesis is complex, which may be associated with the high contents of fluoride and aluminum in brick-tea.