南非黑人角膜参数与屈光不正、眼轴长度、前房深度和晶状体厚度的相关性（英文）

Corneal parameters and their correlations with refractive error,axial length,anterior chamber depth and lens thickness in black South Africans

目的:收集南非健康黑人的角膜直径(CD)、曲率(ACC)和角膜中央厚度(CCT)的数据并探讨其与屈光不正等效球镜(SE)、眼轴长度(AL)、前房深度(ACD)、晶状体厚度(LT)的相关性,及三个角膜参数之间的相关性。方法:选取600例受试者,包括305例男性和295例女性(平均年龄:28.15±13.1y,年龄范围:10~66y)接受全面的眼科检查,包括验光,裂隙灯和眼底镜检查。Oculus Keratograph 4检测CD和ACC,ivue-100光学相干断层扫描检测CCT。Nidek AR-310A自动验光仪和主观验光检测屈光不正。Nidek US-500 A超检测AL,ACD和LT。结果:由于左右眼参数评估的差异无统计学意义,此处只显示右眼的结果。角膜各项参数平均值如下:CD=11.77±0.32 mm(10.30-13.70 mm),ACC=7.88±0.29 mm(7.13~8.88 mm),CCT=493.05±33.2μm(412~590μm)。CD与SE无相关性(r=0.05,P=0.24)。CD与AL(r=0.58,P=0.00)、ACD(r=0.63,P=0.00)显著相关,但与LT(r=-0.40,P=0.00)呈负相关。ACC与SE(r=-0.03,P=0.48)无显著相关性。ACC与AL(r=0.40,P=0.00)呈正相关。ACC与ACD(r=0.04,P=0.56)、LT(r=-0.03,P=0.88)无显著相关性。CCT与角膜以外其他参数间无显著相关性。角膜各项参数的相关性表明,CD与ACC(r=0.71,P=0.00)、CCT(r=-0.68,P=0.00)相关。结论:CD与AL、ACD、LT相关,ACC与AL相关。CCT与角膜以外其它参数无相关性,是一个独立的因素。在角膜各项参数中,CD与ACC、CCT相关。

·AIM：To establish profiles of corneal diameter （ CD ） , curvature （ ACC ） , corneal central thickness （ CCT ） and investigate their correlations with refractive errors＇ spherical equivalent （SE）, axial length （AL）, anterior chamber depth （ACD） and crystalline lens thickness （ LT） in black South Africans with healthy eyes. We also investigated the intercorrelation among the three corneal parameters. ·METHODS：Eyes of six hundred subjects that included 305 males and 295 females （ mean age： 28. 15±13. 1y, range： 10 - 66y ） underwent a complete ophthalmic examination including refraction, slit lamp and ophthalmoscopy. CD and ACC were measured using the Oculus Keratograph 4 （ OCULUS Optikgerte GmbH） , and the CCT was measured with the iVue-100 （ Optovue, Inc. ） optical coherence tomography. Refractive errors were assessed with the Nidek AR-310A auto-refractor and then subjective refraction. The AL, ACD and LT were measured with the Nidek US-500 A-scan ultrasound device. ·RESULTS：There are no statistically significant between the parameters of the right and left eyes assessed, and therefore only the results of the right eyes are presented here. The mean corneal parameter values were： CD=11. 77±0. 32 mm （range=10. 30-13. 70 mm）, ACC=7. 88±0. 29 mm （range=7. 13-8. 88 mm） and CCT=493. 05±33. 2 μm （ range=412-590μm）. CD did not correlate with SE （r=0. 05, P=0. 24）. However, CD was correlated significantly with AL （ r =0. 58, P=0. 00） and ACD （r=0. 63, P=0. 00） but inversely correlated with LT （r= -0. 40, P= 0. 00）. There was no significant correlations between ACC and SE （r=-0. 03, P=0. 48）. ACC correlated positively with AL （ r=0. 40, P=0. 00 ） . There were no significant correlations between ACC and ACD （r=0.04, P=0.56）, and LT （r=-0. 03, P=0. 88 ） . Also, there was no correlation between CCT and other ocular dimensions assessed. However, correlations among corneal parameters showed that CD correlated with ACC （r=0. 71, P=0. 00） and CCT （r=-0. 68, P=0. 00）. ·CONCLUSION：While CD correlated with AL, ACD and LT, the ACC correlated with AL. CCT did not correlate with any of the metrics studied here, suggesting that it is an independent factor unrelated to other ocular dimensions. Among corneal parameters, CD correlated with ACC and CCT.