原发性开角型青光眼患者有氧运动前后脉络膜厚度变化分析（英文）

Response of choroidal thickness to aerobic exercise in subjects with primary open-angle glaucoma

目的:研究原发性开角型青光眼患者有氧运动前后脉络膜厚度的变化。方法:研究选取17例正常受试者(对照组)及17例原发性开角型青光眼患者(试验组)进行有氧运动(慢跑),运动前后依次记录脉络膜厚度(ChT),眼压(IOP)及平均动脉压数值(MAP)。结果:1)运动后对照组及试验组ChT及IOP均出现显著性降低,其中,试验组运动后ChT及IOP降低幅度更为显著。2)运动后对照组及试验组MAP均出现显著性升高,而对照组MAP升高幅度更为明显。3)受试者工作曲线分析提示:对照组与试验组运动前后ChT变化量及IOP变化量曲线下面积分别为0.75及0.281。结论:有氧运动所诱导的交感神经活性升高可能是运动后ChT及IOP降低,MAP升高的主要原因。而POAG患者自主神经功能紊乱是导致运动后ChT,IOP及MAP与正常人存在不同反应性的主要因素。

·AIM：To determine if aerobic exercise results in changes in choroidal thickness （ ChT ） responses in subjects with＆amp;nbsp;primary open-angle glaucoma （ POAG） . ·METHODS： The study included 17 normal participants and 17 POAG patients （ 34 eyes ） and subjected them to aerobic exercise in the form of jogging. During exercise, ChT, intraocular pressure （ IOP ） , and mean arterial pressure （ MAP） were recorded sequentially. ·RESULTS： ChT and IOP significantly decreased in both groups after exercise, and the significant disparate response was found in the control and POAG group （ P〈0. 05）. MAP increased significantly in both groups after exercise, and the increase was more significant in the control group than that in the POAG group. The values for area under the curve （ AUC） of the ChT variations and IOP were 0. 75 and 0. 281, respectively. ·CONCLUSION： Activation of the sympathetic nerve induced by aerobic exercise might be the underlying mechanism for the decrease in ChT and IOP and the increase in MAP in both groups. The disparate responses to jogging observed in ChT, IOP, and MAP values between the groups might be because of the autonomic nervous system dysfunction in POAG patients.