视动反应检测在啮齿类动物视网膜病变应用中的研究进展

Research progress of optkinetic testing applicated on the retinal pathological changes in rodents

目前,视网膜病变的研究中如何解释、评估光感受器细胞的损伤、死亡与视功能的对应关系是一个难题。近年来,视动头部跟踪被用于啮齿类动物,这对光感受器细胞的损伤、死亡与视功能的评估提供了可能。行为学评估在动物视功能的连续性评估中有很大的优势,其相关研究已取得一定的进展。针对目前啮齿类动物视网膜病变视动力测试的研究状况,对视动应答所研究的设备原理,革新及应用等取得的成绩和存在的问题进行综述,为啮齿类动物视网膜病变实验研究中更好地选择合适的检测方法提供依据。

·At present, it is a problem to interpret and evaluate the relation of the damage and the death of photoreceptor cells with visual function in the study of retinal diseases. In recent years, the application of visual head tracking in rodents makes it possible to evaluate the relation of the damage and the death of photoreceptor cells with visual function. Behavioral evaluation, of which the relative study has made some progress, is predominate in continuous evaluation of animal＇s visual function. According to present researches of optkinetic testing on rodent animal with retinal diseases, the principles, the innovations, the achievements and the problems in application of the equipment in optkinetic response research are summarized to provide evidence when testing methods are being chosen in the study of animals with retinal diseases.