摘要
目的分析结肠癌患者手术前后凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)及D-二聚体(D-dimer)变化幅度与患者近期预后的相关性。方法选取2011年1月至2015年1月间收治的120例结肠癌患者作为研究对象,患者术前凝血、纤溶指标检查无明显异常,患者手术前1天及术后第2天清晨抽取空腹血检测PT、APTT及D-dimer,记录变化幅度并分析其与患者病理特征、并发症发生率的关系。结果 120例患者的PT变化幅度(1.1±0.4)s,APTT变化幅度(5.4±2.4)s,D-dimer变化幅度(112.5±31.4)μg/L。术后发生血栓及栓塞12例(10.0%),出血9例(7.5%)。PT、APTT及D-dimer变化幅度与患者术后并发症的发生率具有显著相关性(P<0.05)。结论术前或术后凝血纤溶指标无明显异常的结肠癌患者术后仍有发生血栓、栓塞及出血等疾病的风险,手术前后出现凝血、纤溶指标大幅度变化的患者术后并发症的发生风险更高,临床上应重视对此类患者的术后监测。
Objective To analyze the correlation between prognosis and changes of PT, APTT and D-dimer before and after operation in patients with colon carcinoma. Methods Between January 2011 and January 2015, one hundred and twenty patients with colon carcinoma were chosen as study objects, the level of PT, APTT and D-dimer in patients were detected 1 day before operation, 2 days after operation, and the variations were recorded and analyzed combined with pathological characteristics and complication rate. Results The variation of PT was（1.1±0.4） s, that of APTT was（5.4±2.4） s, that of D-dimer was（112.5±31.4） μg/L. After operation, hemorrhage occurred in 9 patients（7.5%）, 12 patients（10.00%） developed thrombosis and embolism. The variations of PT, APTT and D-dimer demonstrated significant relativity with complications of patients（P〈0.05）. Conclusions Patients with colon carcinoma have risks of thrombosis, embolism and hemorrhage, even with no obvious abnormality on coagulation fibrinolytic markers in perioperation period. It should pay attention to clinical monitoring after opreation.
出处
《中华普通外科学文献（电子版）》
2017年第1期32-35,共4页
Chinese Archives of General Surgery(Electronic Edition)
