甲钴胺与α-硫辛酸治疗2型糖尿病周围神经病变40例临床效果分析

Clinical analysis of mecobalamin and α-lipoic acid in the treatment of 40 cases of type 2 diabetes peripheral neuropathy

目的观察甲钴胺与α-硫辛酸治疗2型糖尿病周围神经病变的临床效果。方法将80例2型糖尿病周围神经病变患者随机分为对照组和观察组,两组均给予常规治疗。对照组在常规治疗的基础上加用甲钴胺治疗,观察组在对照组的基础上加用α-硫辛酸治疗,比较两组治疗效果。结果观察组治疗后总有效率达97.50%,显著高于对照组的80.00%(P<0.05)。治疗前,两组的MNSI、MDNS评分及MNCV、SNCV、最短F波潜伏期比较,无明显差异(P>0.05);治疗后,两组患者的五项指标均有明显改善,且观察组改善情况显著优于对照组(P<0.05)。结论甲钴胺联合α-硫辛酸治疗2型糖尿病周围神经病变,临床效果显著,神经功能改善明显,神经传导速度显著加快,值得临床推广应用。

Objective To observe the clinical effect of mecobalamine and α-lipoic acid for the treatment of type 2 diabetes peripheral neuropathy. Methods Eighty cases of patients with type 2 diabetes peripheral neuropathy were randomly divided into two groups, the patients in the two groups were given the conventional treatment. The control group received the mecobalamine, and the observation group accepted the α-lipoic acid on the basis of the control group, the treatment effects in the two groups were compared. Results The total effective rate of the observation group was 97.50%, which was significantly higher than 80.00% of the control group （P〈0.05）. Before the treatment, there was no significant difference in MNSI, MDNS scores and MNCV, SNCV, the shortest incubation period of F wave in the two groups （P〉0.05）; after the treatment, the five indexes in the two groups were all improved, and the five indexes in the observation group was significantly better than those in the control group （P〈0.05）. Conclusion The mecobalamine combined with α-lipoic acid in the treatment of type 2 diabetes peripheral neuropathy has a remarkable clinic effect, which can significantly improve the nerve function and accelerate the nerve conduction. It is worthy of clinical popularization and application.