CEA、NSE和SCC—Ag在肺癌合并恶性胸腔积液的诊断和评估近期疗效的价值

Value of CEA, NSE and SCC-Ag in the diagnosis and evaluation of the short term efficacy of lung cancer complicated with malignant pleural effusion

目的研究肺癌合并恶性胸腔积液患者肿瘤标志物癌胚抗原（CEA）、特异性神经元烯醇化酶（NSE）、鳞状细胞癌抗原（SCC-Ag）对诊断及近期疗效评估的临床意义。方法选取肺癌合并恶性胸腔积液患者作为研究组，良性胸腔积液患者作为对照纽，采用电化学发光法对两组血清及胸水中的CEA、NSE、SCC—Ag水平进行检测，同时观察化疗后研究纽血清CEA、NSE、SCC—Ag水平。结果研究组血清及胸水CEA、NSE、SCC—Ag水平均高于对照组，差异有统计学意义（P〈0．05）。化疗有效亚组治疗后血清CEA、NSE、SCC．Ag水平均较治疗前明显降低（P〈0．05）。而化疗失败亚组治疗后血清CEA水平较治疗前明显升高，血清NSE、SCC．Ag水平较治疗前无明显改变（P〉0．05）。结论肺癌合并恶性胸腔积液患者CEA、NSE、SCC—Ag水平对诊断具有指导性意义，且CEA水平能指导近期化疗效果的判断。

Objective To study the value of carcinoembryonic antigen （ CEA）, specific neuron specific enolase（NSE）, squamous cell carcinoma antigen（SCC） in the diagnosis and evaluation of the short term efficacy of lung cancer complicated with malignant pleural effusion. Methods The lung cancer patients with malignant pleural effusion were selected as study group, and the patients with benign pleural effusion were selected as control group. Electrochemical luminescence method was used for detedction of the serum and hydrothorax CEA, NSE and SCC Ag levels. Results The serum and hydrothorax levels of CEA, NSE, SCC-Ag in the study group were significantly higher than those in the control group, and there were significant differences（P 〈0. 05 ）. The serum levels of CEA, NSE and SCC-Ag significantly decreased after chemotherapy in the study group （P 〈 0. 05 ）. The serum level of CEA in the chemotherapy failure group was significantly higher than that before treatment （P 〈 0.05 ）. Conclusions The levels of CEA, NSE and SCC-Ag has instructive significance in lung cancer patients with malignant pleural effusion, and the CEA level can guide the judgment of the short-term effect of chemotherapy.