髓外浆细胞瘤38例临床分析

Clinical analysis of 38 patients with extramedullary plasmacytoma

目的探讨髓外浆细胞瘤（EMP）的临床特点，并对其预后进行回顾性分析。方法收集郑州大学第一附属医院38例EMP患者的临床资料，并对其进行随访，应用Kaplan-Meier法对其临床特点、治疗及预后因素行回顾性分析。结果中位随访12个月（0～55个月），临床治愈20例，部分缓解7例，失访4例，复发1例，死亡5例，1例进展为多发性骨髓瘤（MM）2个月后死亡。38例EMP患者年龄5～87（58.1±2.4）岁，中位年龄59.5岁，男女比1.1∶1。38例EMP患者组与同期收治的168例MM患者组，Log-rank检验显示两条生存曲线比较差异未见统计学意义（χ^2＝1.245，P＝0.265）。结论EMP组与MM组近期生存率无差别；EMP好发于中老年男性，部分可转化为MM。

Objective To investigate the clinical characteristics of extramedullary plasmacytoma（EMP）, and retrospectively analyze the prognosis of EMP.Methods The clinical data of 38 patients with EMP in the first affiliated hospital of Zhengzhou university were collected, and carried on the follow-up, Kaplan-Meier method was applied to retrospectively analyze the clinical characteristics, treatment and prognostic factors.Results The median follow-up time was 12 months（0-55 months）. In study group, 20 cases got complete remission（CR）, seven cases had partial remission（PR）, 4 cases lost follow-up, one case had recurrence, five cases died, one case progressed to multiple myeloma（MM） and died after two months. Among the 38 cases, the age ranged 5-87 （58.1±2.4） years old, male and female tatio was 1.1∶1. Log-rank chi-square test showed, the survival curves of 38 patients with EMP and 168 cases of multiple myeloma（MM） in the same time had no significant difference（χ^2=1.245, P=0.265）.Conclusions There is no significant difference in the recent survival rate of EMP group and MM group; middle and old males are more likely to develop EMP, some of them can progress to MM.