IGF-1、TNF—α在子宫腺肌病的表达及意义

Expression of IGF-1 and TNF-α and their significance in adenomyosis

目的研究子宫腺肌病患者胰岛素样生长因子-1（IGF-1）、肿瘤坏死因子-ɑ（TNF-ɑ）在子宫不同部位的表达情况，探讨IGF-1与TNF-ɑ在子宫腺肌病发病机制中的作用。方法选取30例子宫腺肌病患者作为实验组，30例正常妇女作为对照组，采用免疫组化法检测子宫不同部位（包括子宫内膜层、子宫内膜-肌层交界区、外肌层）中IGF-1、TNF-ɑ表达，及二者之间的关系。结果IGF-1、TNF-ɑ在实验组子宫内膜层、子宫内膜-肌层交界区、外肌层的表达均高于对照组，差异有统计学意义（P均〈0.05）；实验组子宫内膜-肌层交界区的表达高于子宫内膜层、外肌层表达，差异有统计学意义（P均〈0.05），对照组表达差异性均未见统计学意义（P均〉0.05）。在实验组中IGF-1与TNF-ɑ表达呈正相关（r＝0.523，0.862，0.447，P均〈0.05）。结论IGF-1、TNF-ɑ可能通过改变子宫内膜-肌层交界区的结构和（或）功能促进子宫腺肌病的发生发展；IGF-1与TNF-ɑ在子宫腺肌病发生发展中可能具有某种协同作用。

Objective To investigate the expression of tumor necrosis factor- ɑ（TNF-ɑ） and IGF-1 in the different position of the uterus, and investigate its effect in adenomyosis.Methods A total of 30 adenpmyosis cases were sellected as experiment group; meanwhile, 30 healthy cases were sellected as control group.Immunohistochemical method was used to detect the expression levels of TNF-ɑ and IGF-1 in different position of the uterus（including endometrium, endometrial-myometrial border and outer myometrium） in experiment group and control group.Results TNF-ɑ and IGF-1 expression were higher in experiment group than that in control group in uteru samples （all P〈0.05）; the endometrial-myometrial border expression was higher than endometrium, outer myometrial in experiment group（all P〈0.05）. And there was no significant difference in the control group（all P〉0.05）. The expression intensity of TNF-ɑ was correlated with IGF-1 in experiment group（r=0.523, 0.862, 0.447, P all〈0.05）.Conclusions IGF-1 and TNF-ɑ may act by changing structure and function of the endometrial-myometrial border; IGF-1 and TNF-ɑ may have some kind of synergistic effect in adenomyosis.