丁苯酞对老年急性脑梗死的疗效及对血清尿酸、C反应蛋白和血液流变学的影响

Efficacy of butylphthalide on elderly patients with acute cerebral infarction and its effect on serum uric acid,c-reactive protein,and hemorheology

目的研究丁苯酞对老年急性脑梗死的疗效及对血清尿酸、C反应蛋白和血液流变学的影响。方法选择2015年1月—2015年12月在西安市第一医院进行诊治的老年急性脑梗死患者86例,随机分为两组,对照组采用常规急性脑梗死对症治疗,观察组加用丁苯酞胶囊。观察两组的美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数和疗效,检测并比较治疗前后两组患者血清尿酸、C反应蛋白、血小板聚集率和血黏稠度。结果观察组的有效率为90.70%,明显高于对照组的72.09%(P<0.05);治疗后两组的NIHSS评分、血清尿酸和C反应蛋白水平、血小板聚集率和血黏稠度均明显降低,Barthel指数明显升高(P<0.05),且观察组的变化较对照组更为明显(P<0.05)。结论丁苯酞对老年急性脑梗死患者的疗效显著,能降低患者的血清尿酸、C反应蛋白水平和神经功能缺损程度,改善其血液流变学状态和生活自理活动能力,具有脑保护作用。

Objective To investigate the efficacy ofbutylphthalide on elderly patients with acute cerebral infarction and its effect on serum uric acid, c-reactive protein, and hemorheology. Methods Elderly patients （86 cases） with acute cerebral infarction in Xi＇an No. 1 Hospital from January 2015 to December 2015 were randomly divided into two groups. The control group was treated with conventional symptomatic treatment of acute cerebral infarction, observation group added with butylphthalide soft capsules. The NIHSS score and efficacy of the two groups, the serum uric acid, c-reactive protein, and the change of hemorheology before and after treatment were compared. Results The effective rate of observation group was 90.70%, significantly higher than that of control group 72.09% （P 〈 0.05）; The NIHSS score, serum uric acid and c-reactive protein levels, blood viscosity and platelet aggregation rate of two groups after treatment were significantly lower （P 〈 0.05）, the Barthel index were significantly increased （P 〈 0.05）, and the change of observation group were more significant （P 〈 0.05）. Conclusion Butylphthalide has high curative effect on elderly patients with acute cerebral infarction, can reduce the level of serum uric acid, c-reactive protein and the degree of nerve function defect, improve the hemorheology and life self-care activities ability, which can protect the brain.