康柏西普眼内注射对糖尿病性视网膜病变行玻璃体切割手术的影响分析

Analysis of the influence of conbercept intraocular injection to vitrectomy on diabetic retinopathy

目的探讨康柏西普眼内注射对糖尿病性视网膜病变行玻璃体切割手术的影响。方法选取100例糖尿病视网膜病变患者,按术前眼内是否注射药物分为两组,注射组(49例)玻璃体切割术前7 d眼内注射康柏西普,对照组(51例)单纯行玻璃体切割术。通过观察并记录患者手术情况、预后情况、术前术后视力情况,评价康柏西普眼内注射对糖尿病性视网膜病变行玻璃体切割手术的影响。结果与对照组相比,注射组所需手术时间更短(P<0.05),注射组出血眼数6例,对照组出血眼数20例,注射组出血眼数明显少于对照组(P<0.05)。此外,注射组术中电凝眼数、硅油使用眼数、医源性裂孔眼数均明显少于对照组(P<0.05);术后随访1个月,注射组少量出血例数和大量活动性出血例数均明显少于对照组(P<0.05);术前两组视力相比,差异没有统计学意义(P<0.05)。术后1个月,两组视力均明显提高且注射组视力明显高于对照组(P<0.05)。结论康柏西普眼内注射有利于玻璃体切割手术的进行,可降低手术难度,缩短手术时间,减少术中、术后出血症状,提高患者矫正视力。

Objective To discuss the influence of conbercept intraocular injection to vitrectomy on diabetic retinopathy. Methods patients （100 cases） with diabetic retinopathy were divided into two groups according to whether use intraocular injection drug or not. The injection group （49 cases） was given conbercept intraocular injection before vitrectomy. The control group （51 cases） was only given vitrectomy. The influence of conbercept intraocular injection to vitrectomy on diabetic retinopathy was evaluated by surgery, prognosis, visual acuity before and after surgery. Results The surgery time of the injection group was shorter than that of the control group （P 〈 0.05）. There were six bleeding cases in the injection group and 20 cases in the control group. The number of bleeding of injection group was shorter than that of the control group （P 〈 0.05）. In addition, the electric coagulation, silicone oil use, iatrogenic macular holes number of injection group was smaller than of that of the control group （P 〈 0.05）. During 1 month follow-up, the number of small bleeding and large bleeding cases of injection group was smaller than of the control group （P 〈 0.05）. There was no statistical significance on vision between two groups. After 1 month surgery, the vision of two groups were increased. And the vision of injection group was significantly higher than that of the control group （P 〈 0.05）. Conclusion In summary, conbercept intraocular injection could help vitrectomy. It could reduce the difficulty of surgery and shorten the surgery time. It could reduce the bleeding symptoms during and after surgery. It could improve the vision of patients.