连接蛋白43与睾丸肿瘤相关性的研究进展

Correlation of connexin 43 with testicular tumors

由连接蛋白(Cx)构成,缝隙连接(GJ)是相邻细胞间的一种特殊膜结构,它调控着细胞的增殖和分化。研究表明,在多数肿瘤细胞中缝隙连接功能出现减弱或丧失,这种异常常伴随着连接蛋白表达的改变。连接蛋白43是睾丸组织中主要的连接蛋白,现就连接蛋白Cx43在睾丸肿瘤方面的研究进展作一综述。

Gap junctions （GJ）, as a special membrane structure between adjacent cells, are composed of connexins （Cx） and regulate the proliferation and differentiation of cells. Studies show that gap junctional intercellular communication is weakened or lost in most tumor cells and this abnormality is often accompanied by changed expression of Cxs. Cx43 is a major connexin in the testis tissue. This review focuses on the latest progress in the studies of Cx43 in testicular tumors.