乳腺癌组织中FOXM1和PLK1的表达及意义

Expression and Clinical Significance of Forkhead Box M1 and Polo-like Kinase 1 in Breast Carcinoma Tissues

目的探讨叉头框转录因子M1(FOXM1)及Polo样激酶1(PLK1)在乳腺癌组织中的表达及临床意义。方法采用免疫组织化学法检测FOXM1及PLK1蛋白在803例乳腺浸润性导管癌和乳腺癌旁组织中的表达情况及其与乳腺癌组织临床病理特征间的关系。结果 FOXM1及PLK1在乳腺浸润性导管癌组织中的阳性表达率分别为59.78%(480/803)和27.90%(224/803),显著高于其在乳腺癌旁组织中的表达(29.89%,0),差异具有统计学意义(χ~2=145.011,χ~2=260.307,P=0.000)。FOXM1及PLK1蛋白的表达与乳腺癌的组织学分级、淋巴结转移及临床分期相关,而与肿瘤大小无关,且二者表达具有正相关关系(r=0.414,P<0.01)。结论 FOXM1及PLK-1可能协同参与了乳腺癌的发生、发展,并可能成为乳腺癌预后评估的重要指标。

Objective To investigate the expression and clinical significance of forkhead box M1（FOXM1） and polo-like kinase 1（PLK1） in breast carcinoma tissues.Methods Immunohistochemical staining was used to detect the expression of FOXM1 and PLK1 in 803 cases of invasive ductal breast carcinoma and paratumor breast tissues,and we evaluated the relationship of FOXM1 and PLK1 expression with the clinical pathological features of invasive ductal breast carcinoma patients,including histological grade,lymph node metastasis and p TNM stage.Results The positive expression rates of FOXM1 and PLK1 protein in invasive ductal breast carcinoma tissues were 59.78%（480/803） and 27.90%（224/803）,significantly higher than those in para-tumor breast tissues（29.89%/0）（χ^2=145.011,χ^2=260.307,P=0.000）.FOXM1 and PLK1 expression were significantly related with the histopathologic grade,lymph node metastasis and p TNM stage,while not correlated with the tumor size.There was a positive relation between the expression of FOXM1 and PLK1（r=0.414,P〈0.01）.Conclusion FOXM1 and PLK1 may be involved in the breast carcinogenesis and progression synergistically,and they might play important roles in the prognosis evaluation of breast carcinoma.