伴快速眼动睡眠期行为障碍的帕金森病临床研究进展

Clinical related study progression of Parkinson＇s disease combined with sleep behavior disorder

快速眼动睡眠期行为障碍（RBD）是快速眼动（REM）睡眠期出现的以肌张力缺失并伴有与噩梦相关的复杂运动为特征的发作性疾病。RBD与PD密切相关，伴RBD的PD患者发病机制可能与黑质纹状体多巴胺能缺陷及脑干核团如蓝斑／蓝斑下区复合体等有关。此部分患者出现率高，非运动症状更重，生活能力及生活质量的损害更突出，除积极干预PD外，应给予RBD患者针对性的预防损伤治疗。

Parkinson＇s disease （PD） is usually characterized by motor symptoms including bradykinesia, rigidity, tremor, and postural instability. Rapid eye movement （REM） sleep behavior disorder （RBD） is characterized by lack of muscle atonia during REM sleep and enactment of dream content. RBD is closely associated with PD. The pathophysiological mechanisms of PD with RBD may be related to defects of nigrostriatal dopamine and locus coeruleus/sub-locus coeruleus complex in brainstem. RBD has high incidence in PD patients, mainly presented with more severe non-motor symptoms, and more prominent life ability and life quality damage. Injury prevention should be given to PD patients with RBD besides positive intervention of PD. We mainly discussed the above contents in this paper.