癫痫持续状态终止机制研究

Recent advance in termination mechanism of status epilepticus

癫痫持续状态（SE）是最常见的神经系统急危重症之一，其发病率、致残率和死亡率均较高，目前已成为倍受重视的公共卫生问题。近年来研究发现内源性抗惊厥物质的参与，兴奋性、抑制性功能失衡的恢复，酸中毒，细胞内外离子浓度变化，以及能量耗竭可能参与了SE的终止过程。本文围绕上述内容针对SE的终止机制综述如下。

Status epilepticus （SE） is one of the most common nervous system diseases, which has high morbidity, disability and mortality. It has become a more important public health problem. Recent studies have found that endogenous anticonvulsant substance participation, imbalance between excitatory and inhibitory function recovery, acidosis, changes of intracellular and extracellular ion concentrations, and energy depletion may participate in the SE termination processes. Based on the above content, termination mechanism of SE are as follows.