β内酰胺类抗生素不同输注方法研究进展

Progress in continuous versus intermittent infusion of β-lactam antibiotics

近年临床研究显示,采用延长输注β内酰胺类抗生素的方法相对于传统间断输注方式可明显改善临床治愈率及微生物清除率,尤其是对最低抑菌浓度(MIC)比较高的病原体。本文将对β内酰胺类抗生素延长输注给药方式的药理学背景与优势、临床获益与弊端、相关的临床疗效研究与问题等进行综述。

Recent clinical research shows that a prolonged infusion administration strategy of β-lactam antibiotics compared with intermittent infusion,may improve microbiologic and clinical cure,especially when pathogens demonstrate higher minimum inhibitory concentrations（MIC）.This article reviews β-lactam pharmacodynamic background and advantages,clinical benefits and risks,clinical efficacy and potential drawbacks of prolonged infusion β-lactam antibiotics.