组蛋白去乙酰化酶与心血管疾病的研究进展

Research Advances of Histone Deacetylase and Cardiovascular Diseases

组蛋白去乙酰化酶(HDAC)是表观遗传的调控子,调控着组蛋白尾,核染色质构象,蛋白-脱氧核酸之间的相互作用,转录及转录后的修饰等。HDAC在心血管疾病的发展中发挥着重要的调控作用,与动脉粥样硬化、心肌重构、高血压、肺动脉高压、心律失常、糖尿病性心肌病、心力衰竭等心血管疾病的发生、发展密切相关。抑制HDAC对心血管的保护发挥着重要作用,可成为心血管疾病的诊断和治疗的新方法,HDAC与HDAC抑制剂已经成为目前心血管疾病领域的研究热点。

Histone deacetylase（HDAC） is an epigenetic regulator,which regulates histone tail,chromatin conformation,interactions between protein and deoxyribonucleic acid,transcriptional and post-transcriptional modification. HDAC play an important role in the development of cardiovascular diseases such as atherosclerosis,myocardial remodeling,hypertension,pulmonary hypertension,arrhythmia,diabetic cardiomyopathy and heart failure. Inhibition of HDAC expression is cardiovascular protective,and can be a new method for the diagnosis and treatment of cardiovascular diseases. Therefore,the HDAC and HDAC inhibitors have become hot spots of the research field of treating and preventing the cardiovascular diseases.