2型糖尿病与舌鳞状细胞癌的临床相关性分析

Investigation on the correlation of type 2 diabetes mellitus with tongue squamous cell carcinoma

目的:探讨2型糖尿病与舌鳞癌发生发展及预后的相关性。方法:分析187例初诊为舌鳞癌患者的临床资料,其中合并2型糖尿病者31例,未合并糖尿病者156例,对比分析两组年龄、性别、空腹血糖、临床分期、病理分级、颈淋巴清扫手术率、淋巴结转移率、肿瘤复发率、术后并发症、平均住院天数。结果:舌鳞癌患者中2型糖尿病患病率是16.6%;糖尿病组及非糖尿病组舌癌晚期患者比例分别为71.0%和44.9%(P<0.05);糖尿病组与非糖尿病组病理分级、颈淋巴清扫手术率和淋巴结转移率差异无统计学意义(P>0.05);糖尿病组肿瘤复发率(32.3%)和术后并发症(16.1%)明显高于非糖尿病组(13.5%和4.5%)(P<0.05)。结论:合并2型糖尿病的舌鳞癌患者初诊时分期较晚,复发率较高。

Objective： To investigate the correlation of type 2 diabetes mellitus （DM） with tongue squamous cell carcinoma（TSCC）. Methods： 187 patients with TSCC were retrospectively analyzed. 31 cases with DM and 156 without DM were included in DM group and Non-DM group respectively. The age, gender, fasting plasma glucose, clinical stage, pathological grade, neck dissection surgery rate, metastatic lymph node rate, tumor recurrence rate, postoperative complications and average number of days of hospitalization of the 2 groups were compared and analyzed. Results： The prevalence of type 2 diabetes mellitus was 16.6% in patients with TSCC. The proportion of the patients with the clinical stage III and IV in DM group and Non-DM group were 71.0% and 44.9% respectively （ P 〈 0.05 ）. There was no significant difference in terms of pathological grades, neck dissection surgery rate and metastatic lymph node rate between the 2 groups（P 〉0.05）. The recurrence rate and postoperative complications of DM group（32.3% and 16.1% ） were higher than those of Non-DM group（ 13.5% and 4.5% ）. Conclusion： Type 2 diabetes mellitus may positively correlate with late clinical stage, high recurrence rate of TSCC.