复方黄芩含漱液与复方氯己定含漱液治疗慢性龈炎的疗效比较

Comparision of compound radix scutellariae gargle with compound chlorhexidine gargle in the treatment of chronic gingivitis

目的:比较复方黄芩含漱液与复方氯己定含漱液治疗慢性牙龈炎的临床疗效及龈沟液中TNF-α的变化。方法:纳入慢性龈炎患者90例,按随机数表法将研究对象分为生理盐水(A)组、复方氯己定组(B)和复方黄芩组(C),每组30例,常规进行口腔洁治,分别在治疗前及治疗后1、2周和1个月记录菌斑指数、牙龈指数,检测龈沟液中TNF-α的含量。结果:4个时间点综合比较,3组患者菌斑指数有统计学差异(F=3.506,P=0.034),B组低于A、C组,而A组和C组无统计学差异(P=0.611);3组患者牙龈指数的差异有统计学意义(F=6.359,P=0.003),A组高于B、C组,而B和C组无统计学差异(P=0.911);3组患者龈沟液中TNF-α的浓度有统计学差异(F=3.780,P=0.027),A组高于B、C组,而B和C组无统计学差异(P=0.923)。结论:复方黄芩含漱液与复方氯己定含漱液缓解慢性牙龈炎炎症的效果相当。

Objective： To compare the clinical effects of gargle fluid containing scutellaria baicalensis with chlorhexidine in the treat- merit of chronic gingivitis and to observe TNF-α expression in gingival crevicular fluid（GCF） before and after treatment. Methods： 90 cases of chronic gingivitis were divided into 3 groups （n = 10） based on random number table and treated by scaling and mouth wash with normal saline （group A）, chlorhexidine（ group B） and scutellaria baicalensis（ group C） respectively. PI and GI were measured, TNF-α level in GCF was examined after initial therapy, 1 week ,2 week and 1 month after treatment. Results： Comprehensive analysis of the whole treatment process showed that there was difference of PI among 3 groups（F =3. 506,P =0.034）. PI in group B was lower than that in group A and C （P 〈 0.05 ; A vs C, P 〉 0.05） ; there was difference of GI among the 3 groups （ F = 6. 359, P = 0. 003 ）. GI in group A was higher than that in group B and C（P 〈0.05; B vs C, P 〉0.05）, there was difference of TNF-α concentration in GCF a- mong the 3 groups （ F = 3. 780,P = 0.027 ） ;TNF-ct in group A was higher than that in group B and C （ P 〈 0.05, B vs C, P 〉 0. 05 ）. Conclusion： Radix scutellariae and chlorhexidine gargle fluid are equally effective in the treatment of chronic gigivitis.