幽门螺旋杆菌感染患者与家庭成员共同治疗的疗效研究

Research on the effect of combined therapy of patients with Helicobacter pylori infection and family members

目的:观察幽门螺旋杆菌(Helicobacter pylori,HP)感染患者与家庭成员共同治疗的临床疗效。方法:以我院2015年2月~2016年2月期间通过C13呼气试验确诊为幽门螺杆菌感染阳性的患者120例为研究对象,将其随机分为对照组与观察组,每组各60例。对照组采用常规四联疗法治疗;观察组中患者及与患者长期共同生活的C13检测阳性的患者家属均给予常规四联疗法治疗,两组均连续治疗10d后停药1月,再次行C13呼气试验检测比较临床疗效。结果:观察组的根除率为91.7%(55/60),明显高于对照组根除率71.7%(43/60),两组间比较差异显著(P<0.05)。结论:HP感染患者与家庭成员共同治疗,可显著提高患者的幽门螺旋杆菌根除率。

Objective：To observe the clinical effect of combined therapy of patients with Helicobacter pylori（HP）infection and family members.Methods：One hundred and twenty patients diagnosed as helicobacter pylori infection by C13 breath test were treated in our hospital from February,2015 to February,2016.All the patients were randomly divided into control group and research group（n=60）.Patients in control group received conventional therapy of quadruple chemotherapy;both of patients and their family members with HP positive in research group were given conventional therapy of quadruple chemotherapy,the continuous treatment of two groups were 10 d.The clinical effect was compared between the two groups：discontinuation 1 month after treatment 10 d,C13expiratory test was evaluated again to analyze the clinical effect.Results：Eradication rate of the observation group was 91.7%（55/60）,which was obviously higher than that of control group（71.7%,P〈0.05）.Conclusion：The combined therapy of patients with Helicobacter pylori infection and family members could significantly improve the Helicobacter pylori eradication rate.