血清脯氨酸肽酶活性与冠状动脉慢血流的关系

Relation between serum prolidase activity and coronary slow flow

目的探讨血清脯氨酸肽酶活性（SPA）与冠状动脉慢血流（CSF）的关系。方法纳入2015年 1—12月因胸痛在首都医科大学附属北京安贞医院就诊的患者80例。根据冠状动脉造影结果分为对照组［冠状动脉正常（3支主要冠状动脉正常且其分支血管内径〉2 mm）且冠状动脉血流量正常的患者］和CSF组（冠状动脉正常但至少有1支冠状动脉存在CSF的患者），各40例。应用心肌梗死溶栓试验帧数（TFC）诊断CSF。采用分光光度法测定SPA。比较2组患者相关参数的差异。结果2组患者基线资料差异无统计学意义（P〉0.05）。CSF组患者的SPA明显高于对照组，差异有统计学意义［（703±14）U/L比（684±13）U/L］（P〈0.01）。SPA与平均TFC呈明显正相关（r=0.463，P〈0.001）。受试者工作特征曲线分析结果显示，SPA截点值为681.3 U/L时，诊断CSF的准确性最高，敏感度和特异度分别为97.5%和52.5%。结论CSF患者的SPA水平升高。SPA与患者的平均TFC明显相关。

ObjectiveTo investigate the relation between serum prolidase activity（SPA） and coronary slow flow（CSF）. MethodsEighty patients with chest pain from January to December 2015 in Beijing Anzhen Hospital, Capital Medical University were enrolled. The patients were divided into control group[normal coronary artery（diameters of 3 main arteries and branch vessels〉2 mm） and normal coronary blood flow] and CSF group（normal coronary artery but at least 1 artery had CSF） according to coronary angiography, with 40 cases in each group. CSF was diagnosed by thrombolysis in myocardial infarction frame count（TFC）. SPA was tested by spectrophotometry. ResultsThere were no significant differences of clinical general data between groups（P〉0.05）. SPA in CSF group was significantly higher than that in control group[（703±14）U/L vs （684±13）U/L]（P〈0.01）. SPA was positively correlated with mean TFC（r=0.463, P〈0.001）. Receiver operator characteristic curve showed that SPA 681.3 U/L had the highest accuracy in diagnosis of CSF, the sensitivity and specificity were 97.5% and 52.5% respectively. ConclusionsPatients with CSF have a high level of SPA; SPA is positively correlated with mean TFC.