曲美他嗪对慢性心力衰竭患者血清炎症因子水平及心功能的影响

Effect of Trimetazidine on serum inflammatory factors levels and cardiac function in patients with chronic heart failure

目的探究曲美他嗪对慢性心力衰竭患者血清炎症因子水平及心功能的影响。方法选择2015年4月—2016年3月我院收治的慢性心力衰竭患者94例,根据随机数表法分为两组,每组47例。对照组实施阿托伐他汀治疗,观察组在此基础上予以曲美他嗪治疗。比较两组患者治疗6个月后血清炎症因子和脑利钠肽(BNP)、心功能以及临床疗效。结果观察组血清C-反应蛋白(CRP)、BNP、肿瘤坏死因子-α(TNF-α)水平均低于对照组,差异有统计学意义(P<0.05);观察组左收缩末期内径(LVESD)、左室舒张末期内径(LVEDd)水平较对照组明显降低,而左室射血分数(LVEF)高于对照组,差异有统计学意义(P<0.05);观察组患者治疗有效率与对照组相比明显提高,差异有统计学意义(P<0.05)。结论对慢性心力衰竭患者实施曲美他嗪治疗,能有效提高患者临床疗效,降低患者血清炎症因子,改善心功能,值得临床推广与应用。

Objective To investigate the effect of Trimetazidine on serum inflammatory factors levels and cardiac function in patients with chronic heart failure （CHF）. Methods 94 CHF patients admitted into our hospital from April 2015 to March 2016 were divided into two groups randomly, 47 cases in each. Control group took Atorvastatin, and on this basis observation group was given Trimetazidine. The serum inflammatory factors levels, brain natriuretic peptide （BNP） , cardiac function and clinical efficacy of two groups after treatment for 6 months were compared. Results The serum C-reactive protein （ CRP）, BNP, Tumor necrosis factor-α （TNF-α） levels of observation group were lower than control group （P 〈 0. 05 ） ; The left ventrieular end-systolic diameter （LVESD）, Left ventricular end-diastolic diameter （LVEDd） levels of observation group significantly decreased compared with control group, but left ventricular ejection fraction （LVEF） was higher than control group （ P 〈 0. 05 ） ; The curative effective rate of observation group significantly increased compared with control group （ P 〈 0.05 ）. Conclusion Trimetazidine for treating CHF patients may effectively increase clinical efficacy, decrease serum inflammatory factors and improve cardiac function, which is worthy of clinical promotion and application.