PTGER4基因多态性与炎症性肠病易感性的Meta分析

Meta-analysis of relationship between PTGER4 genetic polymorphisms and inflammatory bowel disease

目的:系统评价人群中PTGER4基因多态性与炎症性肠病(Inflammatory bowel disease,IBD)的关系。方法:检索Pub Med、Embase、Web of Science中2016年2月29日以前发表的相关病例对照研究文献,选择符合质量要求的研究。用STATA12.0软件进行Meta分析,计算合并OR值及其95%可信区间(Confidence interval,CI),并通过敏感性分析判断结果的稳定性,通过Egger's检验分析发表偏倚。结果:共纳入20篇文献中发表的44项病例对照研究,包括25 179例克罗恩病(Crohn's disease,CD)病例、5 261例溃疡性结肠炎(Ulcerative colitis,UC)病例和44 652名对照。Meta分析结果表明,rs4613763T/C多态性与CD关系的等位基因频率、共显性模型、显性模型、隐性模型分析的合并OR值(95%CI)分别是1.24(1.06~1.45)、1.32(1.06~1.64)、1.25(1.06~1.48)和1.28(1.03~1.59);rs17234657T/G多态性与CD关系四种模型分析合并OR值(95%CI)为:1.43(1.34~1.52)、2.12(1.70~2.63)、1.46(1.36~1.57)和1.93(1.56~2.40);rs4495224A/C多态性与CD关系的四种模型分析合并OR值(95%CI)为:1.05(0.79~1.41)、1.08(0.62~1.88)、1.12(0.75~1.65)和1.00(0.67~1.49);rs9292777G/T多态性与CD关系的四种模型分析合并OR值(95%CI)为:0.77(0.67~0.88)、0.59(0.51~0.69)、0.73(0.61~0.87)和0.68(0.59~0.79);rs1373692T/G多态性与CD关系的四种模型分析合并OR值(95%CI)为:1.23(0.96~1.57)、1.39(0.74~2.59)、1.26(0.74~2.13)和1.31(1.00~1.72)。rs4613763T/C多态性与UC易感性分析的四种模型分析合并OR值(95%CI)为:1.30(1.17~1.44)、1.73(1.16~2.59)、1.32(1.17~1.48)和1.64(1.10~2.45)。结论:rs17234657T/G、rs4613763T/C和rs9292777G/T多态性与CD易感性相关;rs4613763T/C多态性与UC的易感性相关。

Objective： To systematically review the relationship between PTGER4 genetic polymorphisms and the risk of inflammatory bowel disease（ IBD）. Methods： All eligible case-control studies which published up to February 29,2016 were searched by Pub Med,Embase,Web of Science. The studies in accordance with high quality were included in this study. We synthesized pooled odds ratio（ OR） and its 95% confidence interval（ CI） using STATA12. 0. The sensitivity analysis was used to determine the stability of results in meta-analysis. The Egger’s analysis was performed to evaluate the publication bias. Results： Twenty original publications involving 44 case-control studies were included in this study,in which 25 179 patients with Crohn’s disease（ CD）,5 261 patients with ulcerative colitis（ UC） and 44 652 control subjects were detected. The allelic frequency,additive model,dominant model and recessive model were used to analyze the association of rs4613763 T / C polymorphism and CD,and the pooled OR and 95% CI were as followings： 1. 24（ 1. 06-1. 45）,1. 32（ 1. 06-1. 64）,1. 25（ 1. 06-1. 48）,1. 28（ 1. 03-1. 59）. For rs17234657T/G polymorphism and CD,the pooled OR（ 95% CI） of four genetic models were 1. 35（ 1. 28-1. 47）,2. 12（ 1. 70-2. 63）,1. 46（ 1. 36-1. 57） and 1. 90（ 1. 54-2. 35）,respectively. For rs4495224 A / C polymorphism and CD,the pooled OR（ 95% CI） were 1. 05（ 0. 79- 1. 41）,1. 08（ 0. 62- 1. 88）,1. 12（ 0. 75-1. 65） and 1. 00（ 0. 67-1. 49）. And the pooled OR（ 95% CI） were 0. 77（ 0. 67-0. 88）,0. 59（ 0. 51-0. 69）,0. 73（ 0. 61-0. 87）,0. 68（ 0. 59-0. 79） for rs9292777 G / T polymorphism and CD. For rs1373692 T / G polymorphism and CD,the pooled OR（ 95%CI） were 1. 23（ 0. 96-1. 57）,1. 39（ 0. 74-2. 59）,1. 26（ 0. 74-2. 13）,1. 31（ 1. 00-1. 72）. The pooled OR（ 95% CI） of allelic frequency,additive model,dominant model and recessive model for the association of rs4613763 T / C polymorphism with UC were 1. 30（ 1. 17- 1. 44）,1. 73（ 1. 16- 2. 59）,1. 32（ 1. 17- 1. 48）,1. 64（ 1. 10- 2. 45）,respectively. Conclusion： Polymorphisms of rs17234657 T / G,rs4613763 T / C and rs9292777 G / T are associated with CD. Polymorphism of rs4613763 T / C is associated with UC susceptibility.