急性胰腺炎患者严重程度与血清超敏C反应蛋白、同型半胱氨酸、降钙素原和血浆D-二聚体水平相关性的临床研究

Relationship of acute pancreatitis severity with serum Hcy,hs-CRP,PCT and D-D levels

目的探讨急性胰腺炎患者严重程度与血清Hcy、hs-CRP、PCT和D-D水平相关性的临床研究。方法测定113例急性胰腺炎(AP)患者,其中76例轻中症AP(MAP)和37例重症AP(SAP)患者以及60例正常对照组血清Hcy、hs-CRP、PCT和D-D水平,并进行了对比性研究。结果 113例AP患者Hcy、hs-CRP、PCT和D-D水平高于60例正常对照组,差异有统计学意义(P<0.01),113例AP患者血清Hcy、hs-CRP、PCT和D-D的阳性率分别为74.34%、94.69%、92.04%、65.49%。113例AP患者单一血清Hcy、hs-CRP、PCT和D-D单一指标的敏感度分别为66.37%、69.03%、61.95%、60.18%,2个指标联合检测的敏感度为68.14%~72.57%,3个指标联合检测的敏感度为73.45%~74.34%,4个指标联合检测的敏感度为82.30%。结论 AP患者血清Hcy、hs-CRP、PCT和D-D水平以及阳性率和敏感度随疾病的严重程度而增高,这为多指标联合检测AP患者的早期诊断和积极治疗提供了有价值的指标。

Objective To explore the relationship of acute pancreatitis severity with serum Hcy, hs - CRP, PCT and D - D lev- els. Methods The Hcy, hs-CRP, PCT and D-D levels were determined and compared in 113 patients with AP（including 76 cases MAP and 37 cases SAP） and 60 controls. Results The serum Hey, hs - CRP, PCT and D - D levers in 113 patients with AP were significantly higher than those of 60 controls, with the differences statistically significant（ P 〈 0.01 ）. The postive rates of serum Hcy, hs - CRP, PCT and D - D levers in 113 patients with AP were 74.34% , 94.69% , 92.04% and 65.49%, respectively. The individual parameter sensitivity of serum Hcy, hs -CRP, PCT and D -D in 113 patients with AP were 66.37% , 69.03% , 61.95% and 60.18% , respectively, and that of the combined detection of two parameters were with- in 68.14% - 72.57% , that of the combine dection of 3 parameters were within 73.45% - 74.34% , and that of the combined detection of 4 parameters were 82.30%. Conclusion The serum Hey, hs - CRP, PCT and D - D levels and sensitivety in pa- tients with AP increased with severity. This can provide valuable index for the early diagnosis and treatment in patients with AP.