运动干预改善脑学习记忆功能分子机制的研究进展

Research Progress in the Molecular Mechanism of Exercise Intervention on Improving Learning and Memory Function of Brain

无论是脑衰老还是脑缺血,均可导致学习记忆功能下降,而运动干预可通过促进海马相关神经生长因子表达,提高大脑清除自由基的能力,影响海马有关神经递质释放量,改善脑结构及调节脑缺血相关因子的表达等途径改善脑功能。进一步研究证实,这些途径与mi RNA调控脑部基因表达模式的改变有关。目前,国内、外关于运动干预对mi RNA调控脑基因表达的研究甚少,现有研究也多局限于治疗疾病或创伤而采用的运动疗法,缺少脑部mi RNA响应运动训练的直接研究。因此,将研究定位于脑部某一具体部位,进行全方位解析,对该部位响应运动训练而差异表达的mi RNA基因进行鉴定与功能分析,应是今后的研究热点。

Both brain aging and cerebral ischemia can lead to the decline of learning and memory function.Exercise intervention can improve brain function through many ways,such as promoting the expression of nerve growth factor in hippocampus,enhancing free radical scavenging,regulating the release of neurotransmitters in the hippocampus,improving the cerebral morphology and regulating the expression of cerebral ischemia factor.Further studies have confirmed that these pathways are related to the changes in the expression pattern of mi RNA in the brain.However,there is little research about the regulation of brain gene expression by exercise intervention on mi RNA at home and abroad.Current research is also limited to the exercise therapy on some diseases or trauma and lack of direct research on brain mi RNA response motor training.Therefore,it will be the research focus to study a specific part of brain in order to conduct a comprehensive discuss and to identify the mi RNAs which respond to the sports training and analyse their function.